T gamma delta cells and their subsets in blood and synovial fluid from patients with rheumatoid arthritis

Details

Serval ID
serval:BIB_8FED3CC7CD01
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
T gamma delta cells and their subsets in blood and synovial fluid from patients with rheumatoid arthritis
Journal
British Journal of Rheumatology
Author(s)
Lunardi  C., Marguerie  C., Walport  M. J., So  A. K.
ISSN
0263-7103 (Print)
Publication state
Published
Issued date
08/1992
Volume
31
Number
8
Pages
527-30
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
We have determined the distribution of T gamma delta cells in the peripheral blood of 44 patients with rheumatoid arthritis and in 36 healthy controls. In addition, paired blood and synovial fluid samples were obtained from seven patients with RA. The monoclonal antibodies A13, BB3 and Ti gamma A, which are specific for the V delta 1, V delta 2 and V gamma 9 gene products respectively, were used to define T gamma delta subsets. T gamma delta + cells expressed as a percentage of CD3+ lymphocytes were reduced in RA peripheral blood compared with the control group (3.9% +/- 0.5 versus 5.7% +/- 0.7; P less than 0.0001). There was a reduction in the V gamma 9/V delta 2+ subset (from 5.6% +/- 1.2 to 1.7% +/- 0.4) leading to a change in the mean ratio of V delta 2/V delta 1+ cells from 4.3 in normal subjects to 1.1 (P less than 0.002). No statistical difference was observed in T gamma delta cell numbers in synovial fluid compared with the paired blood samples (4.0% +/- 1.1 in blood and 4.4% +/- 1.4 in synovial fluid). Also the distribution of V delta 2+ and V delta 1+ cells was similar in the two compartments and a similar alteration in subset distribution was found in blood and synovial fluid. These findings do not indicate a selective accumulation of a specific T gamma delta subset in RA synovial effusions.
Keywords
Antibodies, Monoclonal Arthritis, Rheumatoid/*blood/*pathology Female Humans Male Phenotype Receptors, Antigen, T-Cell, gamma-delta/*analysis Statistics Synovial Fluid/*cytology T-Lymphocyte Subsets/chemistry/pathology/ultrastructure T-Lymphocytes/chemistry/*pathology/ultrastructure
Pubmed
Web of science
Create date
25/01/2008 8:38
Last modification date
20/08/2019 14:53
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