Potentiation of transmitter release by ciliary neurotrophic factor requires somatic signaling.

Détails

ID Serval
serval:BIB_8FD9BAF8901A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Potentiation of transmitter release by ciliary neurotrophic factor requires somatic signaling.
Périodique
Science (new York, N.y.)
Auteur(s)
Stoop R., Poo M.M.
ISSN
0036-8075 (Print)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
1995
Peer-reviewed
Oui
Volume
267
Numéro
5198
Pages
695-699
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.Publication Status: ppublish
Résumé
Neurotrophic factors participate in the development and maintenance of the nervous system. Application of ciliary neurotrophic factor (CNTF), a protein that promotes survival of motor neurons, resulted in an immediate potentiation of spontaneous and impulse-evoked transmitter release at developing neuromuscular synapses in Xenopus cell cultures. When CNTF was applied at the synapse, the onset of the potentiation was slower than that produced by application at the cell body of the presynaptic neuron. The potentiation effect was abolished when the neurite shaft was severed from the cell body. Thus, transmitter secretion from the nerve terminals is under immediate somatic control and can be regulated by CNTF.
Mots-clé
Acetylcholine/metabolism, Action Potentials/drug effects, Animals, Brain-Derived Neurotrophic Factor, Calcium/metabolism, Cells, Cultured, Ciliary Neurotrophic Factor, Cycloheximide/pharmacology, Dactinomycin/pharmacology, Nerve Tissue Proteins/metabolism, Nerve Tissue Proteins/pharmacology, Neurites/physiology, Neuromuscular Junction/drug effects, Neuromuscular Junction/metabolism, Patch-Clamp Techniques, Receptor, Ciliary Neurotrophic Factor, Receptors, Nerve Growth Factor/metabolism, Signal Transduction, Synapses/drug effects, Synapses/metabolism, Synaptic Transmission, Xenopus
Pubmed
Création de la notice
29/10/2013 10:52
Dernière modification de la notice
20/08/2019 14:53
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