Generation of IL-23 producing dendritic cells (DCs) by airborne fungi regulates fungal pathogenicity via the induction of T(H)-17 responses.

Détails

Ressource 1Télécharger: BIB_8FC2D66043F3.P001.pdf (1577.85 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_8FC2D66043F3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Generation of IL-23 producing dendritic cells (DCs) by airborne fungi regulates fungal pathogenicity via the induction of T(H)-17 responses.
Périodique
Plos One
Auteur(s)
Chamilos G., Ganguly D., Lande R., Gregorio J., Meller S., Goldman W.E., Gilliet M., Kontoyiannis D.P.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2010
Volume
5
Numéro
9
Pages
e12955
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Interleukin-17 (IL-17) producing T helper cells (T(H)-17) comprise a newly recognized T cell subset with an emerging role in adaptive immunity to a variety of fungi. Whether different airborne fungi trigger a common signaling pathway for T(H)-17 induction, and whether this ability is related to the inherent pathogenic behavior of each fungus is currently unknown. Here we show that, as opposed to primary pathogenic fungi (Histoplasma capsulatum), opportunistic fungal pathogens (Aspergillus and Rhizopus) trigger a common innate sensing pathway in human dendritic cells (DCs) that results in robust production of IL-23 and drives T(H)-17 responses. This response requires activation of dectin-1 by the fungal cell wall polysaccharide b-glucan that is selectively exposed during the invasive growth of opportunistic fungi. Notably, unmasking of b-glucan in the cell wall of a mutant of Histoplasma not only abrogates the pathogenicity of this fungus, but also triggers the induction of IL-23 producing DCs. Thus, b-glucan exposure in the fungal cell wall is essential for the induction of IL-23/T(H)-17 axis and may represent a key factor that regulates protective immunity to opportunistic but not pathogenic fungi.
Mots-clé
Air Microbiology, Cells, Cultured, Dendritic Cells/immunology, Dendritic Cells/microbiology, Fungi/immunology, Fungi/pathogenicity, Humans, Interleukin-23/immunology, Leukocytes, Mononuclear/immunology, Leukocytes, Mononuclear/microbiology, Membrane Proteins/immunology, Mycoses/immunology, Mycoses/microbiology, Nerve Tissue Proteins/immunology, Th17 Cells/immunology, beta-Glucans/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/03/2012 12:35
Dernière modification de la notice
08/05/2019 21:56
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