Sugar- and artificially sweetened beverages and intrahepatic fat: A randomized controlled trial.

Détails

ID Serval
serval:BIB_8FA9FBECE647
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sugar- and artificially sweetened beverages and intrahepatic fat: A randomized controlled trial.
Périodique
Obesity (silver Spring, Md.)
Auteur(s)
Campos V., Despland C., Brandejsky V., Kreis R., Schneiter P., Chiolero A., Boesch C., Tappy L.
ISSN
1930-739X (Electronic)
ISSN-L
1930-7381
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
23
Numéro
12
Pages
2335-2339
Langue
anglais
Résumé
OBJECTIVE: To test the hypothesis that substituting artificially sweetened beverages (ASB) for sugar-sweetened beverages (SSB) decreases intrahepatocellular lipid concentrations (IHCL) in overweight subjects with high SSB consumption.
METHODS: About 31 healthy subjects with BMI greater than 25 kg/m(2) and a daily consumption of at least 660 ml SSB were randomized to a 12-week intervention in which they replaced SSBs with ASBs. Their IHCL (magnetic resonance spectroscopy), visceral adipose tissue volume (VAT; magnetic resonance imaging), food intake (2-day food records), and fasting blood concentrations of metabolic markers were measured after a 4-week run-in period and after a 12-week period with ASB or control (CTRL).
RESULTS: About 27 subjects completed the study. IHCL was reduced to 74% of the initial values with ASB (N = 14; P < 0.05) but did not change with CTRL. The decrease in IHCL attained with ASB was more important in subjects with IHCL greater than 60 mmol/l than in subjects with low IHCL. ALT decreased significantly with SSB only in subjects with IHCL greater than 60 mmol/l. There was otherwise no significant effect of ASB on body weight, VAT, or metabolic markers.
CONCLUSIONS: In subjects with overweight or obesity and a high SSB intake, replacing SSB with ASB decreased intrahepatic fat over a 12-week period.
Mots-clé
Adipose Tissue/drug effects, Adipose Tissue/metabolism, Adult, Beverages/adverse effects, Body Weight/drug effects, Dietary Carbohydrates/pharmacology, Female, Humans, Intra-Abdominal Fat/drug effects, Intra-Abdominal Fat/metabolism, Lipid Metabolism/drug effects, Liver/drug effects, Liver/metabolism, Male, Obesity/diet therapy, Obesity/metabolism, Overweight/diet therapy, Overweight/metabolism, Sweetening Agents/pharmacology
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/02/2016 17:43
Dernière modification de la notice
08/05/2019 21:56
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