Sensitivity and specificity of NT-proBNP to detect heart failure at post mortem examination.

Détails

Ressource 1Télécharger: BIB_8F9ED03D5757.P001.pdf (215.45 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_8F9ED03D5757
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sensitivity and specificity of NT-proBNP to detect heart failure at post mortem examination.
Périodique
International journal of legal medicine
Auteur(s)
Sabatasso S., Vaucher P., Augsburger M., Donzé N., Mangin P., Michaud K.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
Publié
Date de publication
11/2011
Peer-reviewed
Oui
Volume
125
Numéro
6
Pages
849-856
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
NT-proBNP, a marker of cardiac failure, has been shown to be stable in post mortem samples. The aim of this study was to assess the accuracy of NT-proBNP to detect heart failure in the forensic setting. One hundred sixty-eight consecutive autopsies were included in the study. NT-proBNP blood concentrations were measured using a chemiluminescent immunoassay kit. Cardiac failure was assessed by three independent forensic experts using macro- and microscopic findings complemented by information about the circumstances of body discovery and the known medical story. Area under the receiving operator curve was of 65.4% (CI 95%, from 57.1 to 73.7). Using a standard cut-off value of >220 pg/mL for NT-proBNP blood concentration, heart failure was detected with a sensitivity of 50.7% and a specificity of 72.6%. NT-proBNP vitreous humor values were well correlated to the ones measured in blood (r (2) = 0.658). Our results showed that NT-proBNP can corroborate the pathological findings in cases of natural death related to heart failure, thus, keeping its diagnostic properties passing from the ante mortem to the post mortem setting. Therefore, biologically inactive polypeptides like NT-proBNP seem to be stable enough to be used in forensic medicine as markers of cardiac failure, taking into account the sensitivity and specificity of the test.

Mots-clé
Aged, Autopsy, Biomarkers/blood, Cause of Death, Female, Heart Failure/blood, Heart Failure/diagnosis, Humans, Luminescent Measurements, Male, Middle Aged, Natriuretic Peptide, Brain/blood, Peptide Fragments/blood, Predictive Value of Tests, Sensitivity and Specificity
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/09/2011 9:14
Dernière modification de la notice
08/05/2019 21:56
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