Diagnosis of myocardial ischemia combining multiphase postmortem CT-angiography, histology, and postmortem biochemistry.

Détails

ID Serval
serval:BIB_8F8C65AB052A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Diagnosis of myocardial ischemia combining multiphase postmortem CT-angiography, histology, and postmortem biochemistry.
Périodique
La Radiologia medica
Auteur(s)
Vanhaebost J., Ducrot K., de Froidmont S., Scarpelli M.P., Egger C., Baumann P., Schmit G., Grabherr S., Palmiere C.
ISSN
1826-6983 (Electronic)
ISSN-L
0033-8362
Statut éditorial
Publié
Date de publication
02/2017
Peer-reviewed
Oui
Volume
122
Numéro
2
Pages
95-105
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The aim of this study was to assess whether the identification of pathological myocardial enhancement at multiphase postmortem computed tomography angiography was correlated with increased levels of troponin T and I in postmortem serum from femoral blood as well as morphological findings of myocardial ischemia. We further aimed to investigate whether autopsy cases characterized by increased troponin T and I concentrations as well as morphological findings of myocardial ischemia were also characterized by pathological myocardial enhancement at multiphase postmortem computed tomography angiography.
Two different approaches were used. In one, 40 forensic autopsy cases that had pathological enhancement of the myocardium (mean Hounsfield units ≥95) observed at postmortem angiography were retrospectively selected. In the second approach, 40 forensic autopsy cases that had a cause of death attributed to acute myocardial ischemia were retrospectively selected.
The preliminary results seem to indicate that the identification of a pathological enhancement of the myocardium at postmortem angiography is associated with the presence of increased levels of cardiac troponins in postmortem serum and morphological findings of ischemia. Analogously, a pathological enhancement of the myocardium at postmortem angiography can be retrospectively found in the great majority of autopsy cases characterized by increased cardiac troponin levels in postmortem serum and morphological findings of myocardial ischemia.
Multiphase postmortem computed tomography angiography is a useful tool in the postmortem setting for investigating ischemically damaged myocardium.

Mots-clé
Autopsy/methods, Biomarkers/blood, Computed Tomography Angiography, Forensic Pathology, Humans, Myocardial Ischemia/blood, Myocardial Ischemia/diagnosis, Predictive Value of Tests, Retrospective Studies, Sensitivity and Specificity, Troponin I/blood, Troponin T/blood
Pubmed
Web of science
Création de la notice
25/10/2016 8:25
Dernière modification de la notice
12/03/2019 11:02
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