Regulatory circuits of T cell function in cancer.

Détails

ID Serval
serval:BIB_8F2CE0F06A85
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Regulatory circuits of T cell function in cancer.
Périodique
Nature Reviews. Immunology
Auteur(s)
Speiser D.E., Ho P.C., Verdeil G.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
16
Numéro
10
Pages
599-611
Langue
anglais
Résumé
Recent progress in cancer immunotherapy emphasizes the importance of understanding immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to mechanisms that are evolutionarily conserved or acquired by somatic mutations. The dysfunctional state of T cells has been termed 'exhaustion', on the basis of similarities to dysfunctional T cells in chronic infections. However, despite shared properties, recent studies have identified marked differences between T cell dysfunction in cancer and chronic infection. In this Review, we discuss T cell-intrinsic molecular alterations and metabolic communication in the tumour microenvironment. Identification of the underlying molecular drivers of T cell dysfunction is essential for the continued progress of cancer research and therapy.
Pubmed
Création de la notice
15/09/2016 20:56
Dernière modification de la notice
03/03/2018 19:21
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