Influenza vaccination in the face of immune exhaustion: Is herd immunity effective for protecting the elderly?

Détails

ID Serval
serval:BIB_8F2B64845B58
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Influenza vaccination in the face of immune exhaustion: Is herd immunity effective for protecting the elderly?
Périodique
Influenza Research and Treatment
Auteur(s)
Lang PO, Samaras D, Samaras N, Govind S, Aspinall R.
ISSN
2090-1380
ISSN-L
2090-1399
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
2011
Numéro
419216
Pages
1-8
Langue
anglais
Notes
pdf: Review Article
Résumé
At the start of the 21st century, seasonal influenza virus infection is still a major public health concern across the world. The recent body of evidence confirms that trivalent inactivated influenza vaccines (TIVs) are not optimal within the population who account for approximately 90% of all influenza-related death: elderly and chronically ill individuals regardless of age. With the ever increasing aging of the world population and the recent fears of any pandemic influenza rife, great efforts and resources have been dedicated to developing more immunogenic vaccines and strategies for enhancing protection in these higher-risk groups. This paper describes the mechanisms that shape immune response at the extreme ages of life and how they have been taken into account to design more effective immunization strategies for these vulnerable populations. Furthermore, consideration will be given to how herd immunity may provide an effective strategy in preventing the burden of seasonal influenza infection within the aged population.
Open Access
Oui
Création de la notice
15/04/2015 10:27
Dernière modification de la notice
08/05/2019 21:54
Données d'usage