Interferon-induced guanylate-binding proteins promote cytosolic lipopolysaccharide detection by caspase-11.

Détails

ID Serval
serval:BIB_8F0B113BC936
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Interferon-induced guanylate-binding proteins promote cytosolic lipopolysaccharide detection by caspase-11.
Périodique
DNA and Cell Biology
Auteur(s)
Meunier E., Broz P.
ISSN
1557-7430 (Electronic)
ISSN-L
1044-5498
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
34
Numéro
1
Pages
1-5
Langue
anglais
Résumé
Lipopolysaccharide (LPS) from gram-negative bacteria is a classical pathogen-associated molecular pattern and a strong inducer of immune responses. While the detection of LPS on the cell surface and in the endosome by Toll-like receptor 4 (TLR4) has been studied for some time, it has only recently been discovered that LPS can also be sensed in the cytosol of cells by a noncanonical inflammasome pathway, resulting in the activation of the cysteine protease caspase-11. Intriguingly, activation of this pathway requires the production of interferons (IFNs) and the induction of a class of IFN-induced GTPases called guanylate-binding proteins (GBPs), which have previously been linked to cell-autonomous killing of intracellular microbes. In this study, we review the recent advances in our understanding of cytosolic LPS sensing and the function of mammalian GBPs.

Mots-clé
Animals, Caspases/physiology, Cytoplasm/enzymology, Cytoplasm/immunology, GTP-Binding Proteins/physiology, Humans, Immunity, Innate, Inflammasomes/physiology, Interferons/physiology, Lipopolysaccharides/pharmacology
Pubmed
Web of science
Création de la notice
25/10/2017 11:05
Dernière modification de la notice
20/08/2019 15:52
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