Lack of Association of Group A Streptococcal Infections and Onset of Tics: European Multicenter Tics in Children Study.

Details

Serval ID
serval:BIB_8EF04D29D2FC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lack of Association of Group A Streptococcal Infections and Onset of Tics: European Multicenter Tics in Children Study.
Journal
Neurology
Author(s)
Schrag A.E., Martino D., Wang H., Ambler G., Benaroya-Milstein N., Buttiglione M., Cardona F., Creti R., Efstratiou A., Hedderly T., Heyman I., Huyser C., Mir P., Morer A., Moll N., Müller N.E., Müller-Vahl K.R., Plessen K.J., Porcelli C., Rizzo R., Roessner V., Schwarz M., Tarnok Z., Walitza S., Dietrich A., Hoekstra P.J.
Working group(s)
European Multicentre Tics in Children Study (EMTICS)
ISSN
1526-632X (Electronic)
ISSN-L
0028-3878
Publication state
Published
Issued date
15/03/2022
Peer-reviewed
Oui
Volume
98
Number
11
Pages
e1175-e1183
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The goal of this work was to investigate the association between group A streptococcal (GAS) infections and tic incidence among unaffected children with a family history of chronic tic disorders (CTDs).
In a prospective cohort study, children with no history for tics who were 3 to 10 years of age with a first-degree relative with a CTD were recruited from the European Multicentre Tics in Children Study (EMTICS) across 16 European centers. Presence of GAS infection was assessed with throat swabs, serum anti-streptolysin O titers, and anti-DNAse titers blinded to clinical status. GAS exposure was defined with 4 different definitions based on these parameters. Cox regression analyses with time-varying GAS exposure were conducted to examine the association of onset of tics and GAS exposure during follow-up. Sensitivity analyses were conducted with Cox regression and logistic regression analyses.
A total of 259 children were recruited; 1 child was found to have tic onset before study entry and therefore was excluded. Sixty-one children (23.6%) developed tics over an average follow-up period of 1 (SD 0.7) year. There was a strong association of sex and onset of tics, with girls having an ≈60% lower risk of developing tics compared to boys (hazard ratio [HR] 0.4, 95% confidence interval [CI] 0.2-0.7). However, there was no statistical evidence to suggest an association of any of the 4 GAS exposure definitions with tic onset (GAS exposure definition 1: HR 0.310, 95% CI 0.037-2.590; definition 2: HR 0.561, 95% CI 0.219-1.436; definition 3: HR 0.853, 95% CI 0.466-1.561; definition 4: HR 0.725, 95% CI 0.384-1.370).
These results do not suggest an association between GAS exposure and development of tics.
This study provides Class I evidence that group A streptococcal exposure does not associate with the development of tics in children with first-degree relatives with chronic tic disorder.
Keywords
Child, Female, Humans, Incidence, Male, Prospective Studies, Streptococcal Infections/complications, Streptococcal Infections/epidemiology, Tic Disorders/epidemiology, Tics/epidemiology
Pubmed
Web of science
Create date
12/02/2022 15:09
Last modification date
02/11/2022 6:41
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