Backseat drivers: the hidden influence of microbial viruses on disease.

Détails

ID Serval
serval:BIB_8EBB90AB458E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Backseat drivers: the hidden influence of microbial viruses on disease.
Périodique
Current Opinion in Microbiology
Auteur(s)
Hartley M.A., Ronet C., Fasel N.
ISSN
1879-0364 (Electronic)
ISSN-L
1369-5274
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
15
Numéro
4
Pages
538-545
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication WOS Document Type: Review
Résumé
Because viral replication depends on the vigour of its host, many viruses have evolved incentives of fitness to pay their keep. When the viral host is a human pathogen, these fitness factors can surface as virulence: creating a Russian doll of pathogenesis where pathogens within pathogens complicate the disease process. Microbial viruses can even be independently immunogenic, as we recently reported for leishmania-virus. Thus, the incidence of this 'hyperpathogenism' is becoming an important clinical consideration and by appreciating the microbial-virus as a backseat driver of human disease, we could exploit its presence as a diagnostic biomarker and molecular target for therapeutic intervention. Here we discuss the prevalence of clinically relevant hyperpathogenism as well as the environmental sanctuaries that breed it.
Pubmed
Web of science
Création de la notice
26/10/2012 19:26
Dernière modification de la notice
20/08/2019 15:52
Données d'usage