Feasibility of in vivo 15N MRS detection of hyperpolarized 15N labeled choline in rats.

Détails

ID Serval
serval:BIB_8EB030AAF06D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Feasibility of in vivo 15N MRS detection of hyperpolarized 15N labeled choline in rats.
Périodique
Physical Chemistry Chemical Physics
Auteur(s)
Cudalbu C., Comment A., Kurdzesau F., van Heeswijk R.B., Uffmann K., Jannin S., Denisov V., Kirik D., Gruetter R.
ISSN
1463-9084[electronic], 1463-9076[linking]
Statut éditorial
Publié
Date de publication
06/2010
Volume
12
Numéro
22
Pages
5818-5823
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo(13)C MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized (15)N labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 +/- 16 s) and in vivo (126 +/- 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized (15)N labeled choline in live animals.
Mots-clé
Animals, Choline/chemistry, Isotope Labeling, Magnetic Resonance Imaging/methods, Male, Nitrogen Isotopes/chemistry, Rats, Rats, Sprague-Dawley
Pubmed
Web of science
Création de la notice
04/08/2010 16:28
Dernière modification de la notice
03/03/2018 19:19
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