Atrial natriuretic peptide administered as intravenous infusion or bolus injection to patients with liver cirrhosis and ascites.

Détails

ID Serval
serval:BIB_8E88887C6EA7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Atrial natriuretic peptide administered as intravenous infusion or bolus injection to patients with liver cirrhosis and ascites.
Périodique
Journal of cardiovascular pharmacology
Auteur(s)
Petrillo A., Scherrer U., Gonvers J.J., Nussberger J., Marder H., de Vane P., Waeber B., Hofstetter J.R., Brunner H.R.
ISSN
0160-2446
Statut éditorial
Publié
Date de publication
1988
Peer-reviewed
Oui
Volume
12
Numéro
3
Pages
279-85
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
The effect of a synthetic atrial natriuretic peptide (h-ANP, 25 amino acids, Wy-47.663) on blood pressure, renal electrolyte excretion, plasma catecholamines, and plasma renin activity was studied in nine patients with cirrhosis of the liver and ascites. The peptide was infused intravenously at 24-h intervals for 2 h in groups of four patients each in two different doses (0.015 and 0.075 micrograms/kg/min or 0.06 and 0.3 micrograms/kg/min). A control experiment with the vehicle was performed in all patients. In three patients h-ANP (1 and 2 micrograms/kg i.v.) was administered as an intravenous bolus injection. Consistent falls in blood pressure were observed during h-ANP infusion only with the two higher doses. The two lower infused doses induced a consistent natriuresis; this renal response was abolished when the two larger doses were used. When given as a bolus, h-ANP had a natriuretic effect comparable to that of the two lower doses of infused h-ANP. Plasma catecholamines and plasma renin activity increased during infusion of the two higher doses of h-ANP. It thus appears that in patients with cirrhosis and ascites, the natriuretic effect of infused h-ANP decreases rather than increases when the doses are raised. Bolus administration of h-ANP may be less prone to trigger counterbalancing responses and side-effects.
Mots-clé
Adult, Atrial Natriuretic Factor, Blood Pressure, Catecholamines, Electrolytes, Female, Heart Rate, Hematocrit, Hormones, Humans, Infusions, Intravenous, Liver Cirrhosis, Male, Middle Aged
Pubmed
Web of science
Création de la notice
25/01/2008 15:04
Dernière modification de la notice
03/03/2018 19:18
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