ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity.

Fougerat, A.; Schoiswohl, G.; Polizzi, A.; Régnier, M.; Wagner, C.; Smati, S.; Fougeray, T.; Lippi, Y.; Lasserre, F.; Raho, I.; Melin, V.; Tramunt, B.; Métivier, R.; Sommer, C.; Benhamed, F.; Alkhoury, C.; Greulich, F.; Jouffe, C.; Emile, A.; Schupp, M.; Gourdy, P.; Dubot, P.; Levade, T.; Meynard, D.; Ellero-Simatos, S.; Gamet-Payrastre, L.; Panasyuk, G.; Uhlenhaut, H.; Amri, E.Z.; Cruciani-Guglielmacci, C.; Postic, C.; Wahli, W.; Loiseau, N.; Montagner, A.; Langin, D.; Lass, A.; Guillou, H.

doi:10.1016/j.celrep.2022.110910

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity.

Details

Download: Fougerat 2022.pdf (4571.67 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0

Serval ID

serval:BIB_8E8213483E10

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity.

Journal

Cell reports

Author(s)

Fougerat A., Schoiswohl G., Polizzi A., Régnier M., Wagner C., Smati S., Fougeray T., Lippi Y., Lasserre F., Raho I., Melin V., Tramunt B., Métivier R., Sommer C., Benhamed F., Alkhoury C., Greulich F., Jouffe C., Emile A., Schupp M., Gourdy P., Dubot P., Levade T., Meynard D., Ellero-Simatos S., Gamet-Payrastre L., Panasyuk G., Uhlenhaut H., Amri E.Z., Cruciani-Guglielmacci C., Postic C., Wahli W., Loiseau N., Montagner A., Langin D., Lass A., Guillou H.

ISSN

2211-1247 (Electronic)

Publication state

Published

Issued date

07/06/2022

Peer-reviewed

Oui

Volume

Number

Pages

110910

Language

english

Notes

Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Abstract

In hepatocytes, peroxisome proliferator-activated receptor α (PPARα) orchestrates a genomic and metabolic response required for homeostasis during fasting. This includes the biosynthesis of ketone bodies and of fibroblast growth factor 21 (FGF21). Here we show that in the absence of adipose triglyceride lipase (ATGL) in adipocytes, ketone body and FGF21 production is impaired upon fasting. Liver gene expression analysis highlights a set of fasting-induced genes sensitive to both ATGL deletion in adipocytes and PPARα deletion in hepatocytes. Adipose tissue lipolysis induced by activation of the β <sub>3</sub> -adrenergic receptor also triggers such PPARα-dependent responses not only in the liver but also in brown adipose tissue (BAT). Intact PPARα activity in hepatocytes is required for the cross-talk between adipose tissues and the liver during fat mobilization.

Keywords

Adipose Tissue/metabolism, Adipose Tissue, Brown/metabolism, Adipose Tissue, White/metabolism, Hepatocytes/metabolism, Ketone Bodies/metabolism, Lipolysis/physiology, PPAR alpha/metabolism, ATGL, CP: Metabolism, FGF21, PPARα, fasting, ketogenesis, lipolysis

URN

urn:nbn:ch:serval-BIB_8E8213483E108

OAI-PMH

oai:serval.unil.ch:BIB_8E8213483E10

DOI

10.1016/j.celrep.2022.110910

Pubmed

35675775

Web of science

000819468000002

Open Access

Yes