Markedly reduced blood pressure responsiveness in endotoxemic rats; reversal by neuropeptide Y.

Détails

ID Serval
serval:BIB_8E74F2DE1946
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Markedly reduced blood pressure responsiveness in endotoxemic rats; reversal by neuropeptide Y.
Périodique
Life sciences
Auteur(s)
Evéquoz D., Waeber B., Corder R., Nussberger J., Gaillard R., Brunner H.R.
ISSN
0024-3205
Statut éditorial
Publié
Date de publication
1987
Peer-reviewed
Oui
Volume
41
Numéro
23
Pages
2573-80
Langue
anglais
Notes
Publication types: Journal Article - Publication Status: ppublish
Résumé
This study in conscious normotensive rats was performed to assess the effect of the vasoconstrictor peptide, neuropeptide Y (NPY), on blood pressure responsiveness to exogenous norepinephrine in endotoxaemia. NPY and endotoxin were infused at doses which had no effect on blood pressure, whether given alone or in combination. Endotoxin markedly reduced the pressor responses to bolus injections of norepinephrine. However, blood pressure responsiveness could be enhanced by infusing NPY simultaneously with the endotoxin. It is suggested that low dose NPY infusions may be clinically useful in reversing the reduced vascular responsiveness to pressor amines in shock.
Mots-clé
Adrenal Medulla, Animals, Blood Pressure, Dose-Response Relationship, Drug, Endotoxins, Infusions, Intravenous, Male, Neuropeptide Y, Norepinephrine, Rats, Rats, Inbred Strains, Sepsis
Pubmed
Web of science
Création de la notice
05/03/2008 17:40
Dernière modification de la notice
03/03/2018 19:18
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