Evaluation of heterogeneity of DNA ploidy in early gastric cancers.

Détails

ID Serval
serval:BIB_8E6BA5DE4323
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evaluation of heterogeneity of DNA ploidy in early gastric cancers.
Périodique
Analytical Cellular Pathology
Auteur(s)
Osterheld M.C., Laurini R., Saraga E., Bosman F.T.
ISSN
0921-8912 (Print)
ISSN-L
0921-8912
Statut éditorial
Publié
Date de publication
1999
Volume
19
Numéro
2
Pages
67-72
Langue
anglais
Résumé
DNA ploidy has been shown to be a predictive parameter for prognosis in various solid tumours. The prognostic value of DNA-ploidy in gastric cancers is still a matter of controversy. A possible explanation for the discrepant results reported in the literature could be sampling error in tumours with multiple stemlines differing in DNA-ploidy. In order to determine whether or not such heterogeneity exists in early gastric carcinoma, we have performed DNA cytophotometry on multiple samples of a group of 17 early gastric carcinomas, of which 8 were pure intramucosal and 9 were infiltrating into the submucosa. We found an aneuploid DNA-stemline in 8 (47%) early gastric cancers, more often in tumours invading into the submucosa (5/9) than in purely mucosal tumours (3/8). Multiple DNA-stemlines were found more frequently in submucosally infiltrating tumours (4/5). These results confirm the presence of DNA-aneuploid early gastric carcinoma which are frequently heterogeneous and suggest that heterogeneity occurs more frequently in tumours invading the submucosa. This heterogeneity is best detected by analysing multiple samples of tumours for DNA-ploidy.
Mots-clé
Adult, Aged, Aged, 80 and over, Aneuploidy, Carcinoma/genetics, Carcinoma/pathology, Diploidy, Female, Gastric Mucosa/pathology, Genetic Heterogeneity, Humans, Lymphatic Metastasis, Male, Middle Aged, Stomach Neoplasms/genetics, Stomach Neoplasms/pathology
Pubmed
Web of science
Création de la notice
03/09/2011 21:19
Dernière modification de la notice
03/03/2018 19:18
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