Glomerular filtration rate: measure creatinine and height rather than cystatin C!

Détails

ID Serval
serval:BIB_8E5626D35E54
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Glomerular filtration rate: measure creatinine and height rather than cystatin C!
Périodique
Acta Paediatrica
Auteur(s)
Martini S., Prévot A., Mosig D., Werner D., van Melle G., Guignard J.P.
ISSN
0803-5253
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
92
Numéro
9
Pages
1052-1057
Langue
anglais
Résumé
AIM: Inulin clearance (Cin) is the gold standard for assessing glomerular filtration rate (GFR). Other methods are based on the plasma creatinine concentration (Pcreat), creatinine clearance (Ccreat), the Haycock-Schwartz formula and the plasma concentration of cystatin C (PcysC), a 13 kDa basic protein produced at a constant rate by all nucleated cells. The present prospective study was thus designed to evaluate the reliability of PcysC as a marker of GFR in comparison with that of Pcreat, Ccreat and the Haycock-Schwartz formula, using Cin as the gold standard. METHODS: Ninety-nine children (51 m/48 f), with a median age of 8.3 y (1.0-17.9) were studied. Using a cut-off for Cin of 100 ml/min per 1.73 m2, 54 children (54.5%) had impaired GFR. Those with normal GFR were comparable for age, height, weight and body mass index. RESULTS: Logistic regression, ROC analysis and linear regression all showed that Ccreat was the best parameter to discriminate between impaired and normal GFR, followed by the Haycock-Schwartz formula, PcysC, and finally Pcreat, each one being significantly more predictive than the next. CONCLUSION: GFR is better assessed by the Haycock-Schwartz formula than by PcysC or Pcreat alone. It is therefore concluded that when urine collection is not possible, simply measuring the child's Pcreat and height is the best, easiest and cheapest way to assess GFR.
Mots-clé
Adolescent, Body Height, Child, Child, Preschool, Creatinine/blood, Creatinine/urine, Cystatin C, Cystatins/blood, Female, Glomerular Filtration Rate, Humans, Infant, Inulin/blood, Inulin/urine, Male
Pubmed
Web of science
Création de la notice
20/07/2009 14:12
Dernière modification de la notice
03/03/2018 19:18
Données d'usage