Secretory immunoglobulin A: from mucosal protection to vaccine development.

Détails

ID Serval
serval:BIB_8E541BF366A1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Secretory immunoglobulin A: from mucosal protection to vaccine development.
Périodique
Biological Chemistry
Auteur(s)
Corthésy B., Spertini F.
ISSN
1431-6730[print], 1431-6730[linking]
Statut éditorial
Publié
Date de publication
11/1999
Volume
380
Numéro
11
Pages
1251-1262
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Immune responses taking place in mucosal tissues are typified by secretory immunoglobulin A (S-IgA) molecules, which are assembled from proteins expressed in two cell lineages. The heavy and light chains as well as the J chain are produced in plasma cells, whereas the secretory component (SC) is associated to the immunoglobulin complex during transcytosis across the epithelial layer. S-IgA antibodies represent the predominant immunoglobulin class in external secretions, and the best defined entity providing specific immune protection for mucosal surfaces by blocking attachment of bacteria and viruses. S-IgA constitutes greater than 80% of all antibodies produced in mucosa-associated lymphoid tissues in humans. The existence of a common mucosal immune system permits immunization on one mucosal surface to induce secretion of antigen-specific S-IgA at distant sites. In addition, S-IgA antibodies not only function in external secretions, but also exert their antimicrobial properties within the epithelial cell during transport across the epithelium. Passive mucosal delivery of monoclonal IgA molecules neutralizes pathogens responsible for gastrointestinal and respiratory infections. Mucosal and systemic immunity can be achieved by orally administered recombinant S-IgA molecules carrying a protective bacterial epitope within the SC polypeptide primary sequence.
Mots-clé
Animals, Antigens/metabolism, Humans, Immunity, Mucosal/drug effects, Immunization, Immunoglobulin A, Secretory/chemistry, Immunoglobulin A, Secretory/genetics, Inflammation/immunology, Recombinant Proteins/genetics, Recombinant Proteins/immunology, Vaccines/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 15:53
Dernière modification de la notice
03/03/2018 19:18
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