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Imaging and therapy with monoclonal antibodies in non-hematopoietic tumors.
Current Opinion in Immunology
Although radiolabelled monoclonal antibodies are useful in tumor imaging, in our opinion their most important role is in the evaluation of the capacity of newly developed monoclonal antibodies to localize in tumors specifically. Intravenous injections of monoclonal antibody fragments, labelled with beta-emitting radionuclides, can completely eradicate large human colon carcinoma xenografts in nude mice whereas this is not achieved by unconjugated monoclonal antibodies. New strategies are being developed to make radioimmunotherapy applicable to carcinoma patients.
Animals, Antibodies, Monoclonal/diagnostic use, Antibodies, Monoclonal/immunology, Colonic Neoplasms/radiotherapy, Humans, Isotopes, Mice, Mice, Nude, Neoplasm Transplantation, Neoplasms/immunology, Neoplasms/radionuclide imaging, Neutrons, Radiation Dosage, Radioimmunodetection, Radioimmunotherapy, Tissue Distribution, Transplantation, Heterologous
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