Astrocytes, from brain glue to communication elements: the revolution continues

Détails

ID Serval
serval:BIB_8E25DD85A9F4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Astrocytes, from brain glue to communication elements: the revolution continues
Périodique
Nature Reviews. Neuroscience
Auteur(s)
Volterra  A., Meldolesi  J.
ISSN
1471-003X (Print)
Statut éditorial
Publié
Date de publication
08/2005
Volume
6
Numéro
8
Pages
626-40
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Aug
Résumé
For decades, astrocytes have been considered to be non-excitable support cells of the brain. However, this view has changed radically during the past twenty years. The recent recognition that they are organized in separate territories and possess active properties--notably a competence for the regulated release of 'gliotransmitters', including glutamate--has enabled us to develop an understanding of previously unknown functions for astrocytes. Today, astrocytes are seen as local communication elements of the brain that can generate various regulatory signals and bridge structures (from neuronal to vascular) and networks that are otherwise disconnected from each other. Examples of their specific and essential roles in normal physiological processes have begun to accumulate, and the number of diseases known to involve defective astrocytes is increasing.
Mots-clé
Animals Astrocytes/*physiology Brain/*cytology/physiology Brain Diseases/*pathology/physiopathology Cell Communication/*physiology Humans
Pubmed
Web of science
Création de la notice
24/01/2008 15:37
Dernière modification de la notice
03/03/2018 19:17
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