Delivery systems and adjuvants for vaccination against HIV.

Détails

ID Serval
serval:BIB_8DD1A8EAB197
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Delivery systems and adjuvants for vaccination against HIV.
Périodique
Pathobiology
Auteur(s)
Velin D., Hopkins S., Kraehenbuhl J.
ISSN
1015-2008 (Print)
ISSN-L
1015-2008
Statut éditorial
Publié
Date de publication
1998
Volume
66
Numéro
3-4
Pages
170-175
Langue
anglais
Notes
Publication types: Lectures ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Epidemiologic studies have revealed that HIV-1 infections occur through contact with contaminated blood or during unprotected vaginal or anal intercourse. Hence, to protect against HIV infection, vaccines should induce both mucosal and systemic immune responses. We present a brief review of the different delivery systems and adjuvants which can be used to elicit mucosal immune responses. Oral or nasal administration of recombinant Salmonella vaccines can induce both mucosal and systemic immune responses against the carried antigen. The oral delivery of mucosal adjuvants (such as cholera toxin) in association with antigens has been shown to enhance mucosal and systemic immune responses against them. Recently developed vaccination strategies using naked DNA or recombinant adenovirus are also discussed.
Mots-clé
AIDS Vaccines/administration & dosage, AIDS Vaccines/immunology, Administration, Oral, Cholera Toxin/immunology, Drug Delivery Systems, HIV Infections/immunology, HIV Infections/prevention & control, Humans, Intestinal Mucosa/immunology, Salmonella typhimurium/immunology, Vaccination/methods, Vaccines, Synthetic/administration & dosage, Vaccines, Synthetic/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 17:10
Dernière modification de la notice
03/03/2018 19:17
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