The main sources of intersubject variability in neuronal activation for reading aloud.

Détails

ID Serval
serval:BIB_8DC84137CD74
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The main sources of intersubject variability in neuronal activation for reading aloud.
Périodique
Journal of Cognitive Neuroscience
Auteur(s)
Kherif F., Josse G., Seghier M.L., Price C.J.
ISSN
0898-929X (Print)
ISSN-L
0898-929X
Statut éditorial
Publié
Date de publication
2009
Volume
21
Numéro
4
Pages
654-668
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The aim of this study was to find the most prominent source of intersubject variability in neuronal activation for reading familiar words aloud. To this end, we collected functional imaging data from a large sample of subjects (n = 76) with different demographic characteristics such as handedness, sex, and age, while reading. The subject-by-subject error variance was estimated from a one-sample t test (on all 76 subjects) and was reduced to a lower dimension using principal components decomposition. A Gaussian Mixture Model was then applied to dissociate different subgroups of subjects that explained the main sources of variability in the data. This resulted in the identification of four different subject groups. The comparison of these subgroups to the subjects' demographic details showed that age had a significant effect on the subject partitioning. In addition, a region-by-group dissociation in the dorsal and the ventral inferior frontal cortex was consistent with previously reported dissociations in semantic and nonsemantic reading strategies. In contrast to these significant findings, the groupings did not differentiate subjects on the basis of either sex or handedness, nor did they segregate the subjects with right- versus left-lateralized reading activation. We therefore conclude that, of the variables tested, age and reading strategy were the most prominent source of variability in activation for reading familiar words aloud.
Mots-clé
Adolescent, Adult, Age Factors, Analysis of Variance, Brain/blood supply, Brain/physiology, Brain Mapping, Child, Female, Functional Laterality/physiology, Humans, Image Processing, Computer-Assisted/methods, Magnetic Resonance Imaging/methods, Male, Middle Aged, Normal Distribution, Oxygen/blood, Phonetics, Principal Component Analysis, Reaction Time/physiology, Reading, Semantics, Young Adult
Pubmed
Web of science
Création de la notice
22/01/2013 15:40
Dernière modification de la notice
03/03/2018 19:16
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