Three-dimensional ordered-subset expectation maximization iterative protocol for evaluation of left ventricular volumes and function by quantitative gated SPECT: a dynamic phantom study.

Détails

ID Serval
serval:BIB_8D7FF1F2BF3E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Three-dimensional ordered-subset expectation maximization iterative protocol for evaluation of left ventricular volumes and function by quantitative gated SPECT: a dynamic phantom study.
Périodique
Journal of Nuclear Medicine Technology
Auteur(s)
Ceriani L., Ruberto T., Delaloye A.B., Prior J.O., Giovanella L.
ISSN
1535-5675 (Electronic)
ISSN-L
0091-4916
Statut éditorial
Publié
Date de publication
2010
Volume
38
Numéro
1
Pages
18-23
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
The purposes of this study were to characterize the performance of a 3-dimensional (3D) ordered-subset expectation maximization (OSEM) algorithm in the quantification of left ventricular (LV) function with (99m)Tc-labeled agent gated SPECT (G-SPECT), the QGS program, and a beating-heart phantom and to optimize the reconstruction parameters for clinical applications.
METHODS: A G-SPECT image of a dynamic heart phantom simulating the beating left ventricle was acquired. The exact volumes of the phantom were known and were as follows: end-diastolic volume (EDV) of 112 mL, end-systolic volume (ESV) of 37 mL, and stroke volume (SV) of 75 mL; these volumes produced an LV ejection fraction (LVEF) of 67%. Tomographic reconstructions were obtained after 10-20 iterations (I) with 4, 8, and 16 subsets (S) at full width at half maximum (FWHM) gaussian postprocessing filter cutoff values of 8-15 mm. The QGS program was used for quantitative measurements.
RESULTS: Measured values ranged from 72 to 92 mL for EDV, from 18 to 32 mL for ESV, and from 54 to 63 mL for SV, and the calculated LVEF ranged from 65% to 76%. Overall, the combination of 10 I, 8 S, and a cutoff filter value of 10 mm produced the most accurate results. The plot of the measures with respect to the expectation maximization-equivalent iterations (I x S product) revealed a bell-shaped curve for the LV volumes and a reverse distribution for the LVEF, with the best results in the intermediate range. In particular, FWHM cutoff values exceeding 10 mm affected the estimation of the LV volumes.
CONCLUSION: The QGS program is able to correctly calculate the LVEF when used in association with an optimized 3D OSEM algorithm (8 S, 10 I, and FWHM of 10 mm) but underestimates the LV volumes. However, various combinations of technical parameters, including a limited range of I and S (80-160 expectation maximization-equivalent iterations) and low cutoff values (< or =10 mm) for the gaussian postprocessing filter, produced results with similar accuracies and without clinically relevant differences in the LV volumes and the estimated LVEF.
Mots-clé
Algorithms, Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography/instrumentation, Heart Ventricles/anatomy & histology, Heart Ventricles/radionuclide imaging, Humans, Image Processing, Computer-Assisted/methods, Normal Distribution, Organ Size, Phantoms, Imaging, Software, Technetium/diagnostic use, Ventricular Function
Pubmed
Open Access
Oui
Création de la notice
18/02/2011 15:32
Dernière modification de la notice
20/08/2019 15:51
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