(<sup>18</sup>F)-FDG PET/CT parameters to predict survival and recurrence in patients with locally advanced cervical cancer treated with chemoradiotherapy.

Détails

ID Serval
serval:BIB_8D0209EBDD82
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
(<sup>18</sup>F)-FDG PET/CT parameters to predict survival and recurrence in patients with locally advanced cervical cancer treated with chemoradiotherapy.
Périodique
Cancer radiotherapie
Auteur(s)
Scher N., Castelli J., Depeursinge A., Bourhis J., Prior J.O., Herrera F.G., Ozsahin M.
ISSN
1769-6658 (Electronic)
ISSN-L
1278-3218
Statut éditorial
Publié
Date de publication
05/2018
Peer-reviewed
Oui
Volume
22
Numéro
3
Pages
229-235
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To identify predictive ( <sup>18</sup> F)-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT)-based parameters for locoregional control, disease-free survival and overall survival, by testing different thresholds of metabolic tumor volume and total lesion glycolysis in patients with locally-advanced cervical cancer.
Thirty-seven patients treated with standard chemoirradiation underwent a pretreatment ( <sup>18</sup> F)-FDG-PET/CT. Using different thresholds of maximum standardized uptake value, the following PET parameters were computed: maximum standardized uptake value, mean standardized uptake value, metabolic tumor volume and total lesion glycolysis for primary tumor and lymph nodes and a new parameter combining the metabolic tumor volume and the distance between lymph nodes and the primary tumor, namely metabolic node distance. Correlation between PET and clinical parameters with clinical outcome (overall survival, disease-free survival, and locoregional control) was assessed using univariate and multivariate analyses (Cox model).
In univariate analyses, PET/CT parameters associated with overall survival and disease-free survival were: metabolic tumor volume and total lesion glycolysis of the primary tumor, total lesion glycolysis of lymph nodes and metabolic node distance. The most predictive threshold segmentation for metabolic tumor volume and total lesion glycolysis was 48% of maximum standardized uptake value for the primary tumor and 30% for the lymph nodes. In multivariate Cox analysis, the total lesion glycolysis of primary tumor 48% and metabolic node distance were the two independent risk factors for overall survival (P<0.01), disease-free survival (P<0.01) and locoregional control (P=0.046).
Total lesion glycolysis of primary tumor and distance between the invaded positive lymph node and the primary tumor seem to have the highest predictive value when compared to classical clinical prognostic parameters and may be useful to identify high risk groups at time of diagnosis and to tailor the therapeutic approach in locally-advanced cervical cancer.
Mots-clé
Adenocarcinoma/diagnostic imaging, Adenocarcinoma/mortality, Adenocarcinoma/pathology, Adenocarcinoma/therapy, Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell/diagnostic imaging, Carcinoma, Squamous Cell/mortality, Carcinoma, Squamous Cell/pathology, Carcinoma, Squamous Cell/therapy, Chemoradiotherapy, Disease-Free Survival, Female, Fluorodeoxyglucose F18, Humans, Middle Aged, Neoplasm Recurrence, Local/mortality, Neoplasm Staging, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals, Survival Rate, Uterine Cervical Neoplasms/diagnostic imaging, Uterine Cervical Neoplasms/mortality, Uterine Cervical Neoplasms/pathology, Uterine Cervical Neoplasms/therapy, ((18)F)-FDG PET, Cancer du col utérin, Cervical cancer, Prognosis, Prognostic, Radiotherapy, Radiothérapie, TEP au ((18)F)-FDG
Pubmed
Web of science
Création de la notice
19/04/2018 19:21
Dernière modification de la notice
03/08/2018 17:48
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