Immune correlates of vaccine protection against HIV-1 acquisition.

Details

Serval ID
serval:BIB_8CEE6DB353F7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Immune correlates of vaccine protection against HIV-1 acquisition.
Journal
Science Translational Medicine
Author(s)
Corey L., Gilbert P.B., Tomaras G.D., Haynes B.F., Pantaleo G., Fauci A.S.
ISSN
1946-6242 (Electronic)
ISSN-L
1946-6234
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
7
Number
310
Pages
310rv7
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublishDocument Type: Review
Abstract
The partial efficacy reported in the RV144 HIV vaccine trial in 2009 has driven the HIV vaccine field to define correlates of risk associated with HIV-1 acquisition and connect these functionally to preventing HIV infection. Immunological correlates, mainly including CD4(+) T cell responses to the HIV envelope and Fc-mediated antibody effector function, have been connected to reduced acquisition. These immunological correlates place immunological and genetic pressure on the virus. Indeed, antibodies directed at conserved regions of the V1V2 loop and antibodies that mediate antibody-dependent cellular cytotoxicity to HIV envelope in the absence of inhibiting serum immunoglobulin A antibodies correlated with decreased HIV risk. More recently, researchers have expanded their search with nonhuman primate studies using vaccine regimens that differ from that used in RV144; these studies indicate that non-neutralizing antibodies are associated with protection from experimental lentivirus challenge as well. These immunological correlates have provided the basis for the design of a next generation of vaccine regimens to improve upon the qualitative and quantitative degree of magnitude of these immune responses on HIV acquisition.
Pubmed
Web of science
Create date
10/01/2016 15:38
Last modification date
20/08/2019 14:51
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