Immune correlates of vaccine protection against HIV-1 acquisition.

Détails

ID Serval
serval:BIB_8CEE6DB353F7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Immune correlates of vaccine protection against HIV-1 acquisition.
Périodique
Science Translational Medicine
Auteur(s)
Corey L., Gilbert P.B., Tomaras G.D., Haynes B.F., Pantaleo G., Fauci A.S.
ISSN
1946-6242 (Electronic)
ISSN-L
1946-6234
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
7
Numéro
310
Pages
310rv7
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublishDocument Type: Review
Résumé
The partial efficacy reported in the RV144 HIV vaccine trial in 2009 has driven the HIV vaccine field to define correlates of risk associated with HIV-1 acquisition and connect these functionally to preventing HIV infection. Immunological correlates, mainly including CD4(+) T cell responses to the HIV envelope and Fc-mediated antibody effector function, have been connected to reduced acquisition. These immunological correlates place immunological and genetic pressure on the virus. Indeed, antibodies directed at conserved regions of the V1V2 loop and antibodies that mediate antibody-dependent cellular cytotoxicity to HIV envelope in the absence of inhibiting serum immunoglobulin A antibodies correlated with decreased HIV risk. More recently, researchers have expanded their search with nonhuman primate studies using vaccine regimens that differ from that used in RV144; these studies indicate that non-neutralizing antibodies are associated with protection from experimental lentivirus challenge as well. These immunological correlates have provided the basis for the design of a next generation of vaccine regimens to improve upon the qualitative and quantitative degree of magnitude of these immune responses on HIV acquisition.
Pubmed
Web of science
Création de la notice
10/01/2016 16:38
Dernière modification de la notice
03/03/2018 19:14
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