Peri-interventional antibiotic prophylaxis only vs continuous low-dose antibiotic treatment in patients with JJ stents: a prospective randomised trial analysing the effect on urinary tract infections and stent-related symptoms.

Details

Serval ID
serval:BIB_8CEE20CF1759
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Peri-interventional antibiotic prophylaxis only vs continuous low-dose antibiotic treatment in patients with JJ stents: a prospective randomised trial analysing the effect on urinary tract infections and stent-related symptoms.
Journal
BJU international
Author(s)
Moltzahn F., Haeni K., Birkhäuser F.D., Roth B., Thalmann G.N., Zehnder P.
ISSN
1464-410X (Electronic)
ISSN-L
1464-4096
Publication state
Published
Issued date
02/2013
Peer-reviewed
Oui
Volume
111
Number
2
Pages
289-295
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
To evaluate the antibiotic treatment regime in patients with indwelling JJ stents, the benefits and disadvantages of a peri-interventional antibiotic prophylaxis were compared with those of a continuous low-dose antibiotic treatment in a prospective randomised trial.
In all, 95 patients were randomised to either receive peri-interventional antibiotic prophylaxis during stent insertion only (group A, 44 patients) or to additionally receive a continuous low-dose antibiotic treatment until stent removal (group B, 51). Evaluations for urinary tract infections (UTI), stent-related symptoms (SRSs) and drug side-effects were performed before stent insertion and consecutively after 1, 2 and 4 weeks and/or at stent withdrawal. All patients received a peri-interventional antibiotic prophylaxis with 1.2 g amoxicillin/clavulanic acid. Amoxicillin/clavulanic acid (625 mg) once daily was administered for continuous low-dose treatment (group B). Primary endpoints were the overall rates of UTIs and SRSs. Secondary endpoints were the rates and severity of drug side-effects.
Neither the overall UTI rates (group A: 9% vs group B: 10%), nor the rates of febrile UTIs (group A: 7% vs group B: 6%) were different between the groups. Similarly, SRS rates did not differ (group A: 98% vs group B: 96%). Antibiotic side-effect symptoms were to be increased in patients treated with low-dose antibiotics.
A continuous antibiotic low-dose treatment during the entire JJ stent-indwelling time does not reduce the quantity or severity of UTIs and has no effect on SRSs either compared with a peri-interventional antibiotic prophylaxis only.
Keywords
Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents/administration & dosage, Antibiotic Prophylaxis/methods, Endoscopy/methods, Female, Humans, Male, Middle Aged, Prospective Studies, Prosthesis Implantation/methods, Prosthesis-Related Infections/prevention & control, Stents/adverse effects, Surveys and Questionnaires, Urinary Tract Infections/prevention & control, Urolithiasis/surgery, Young Adult
Pubmed
Web of science
Create date
08/01/2021 15:30
Last modification date
09/01/2021 6:26
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