Oestrogen receptor polymorphisms and late-life depression.
Details
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_8CCD1F8BBD7C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Oestrogen receptor polymorphisms and late-life depression.
Journal
The British journal of psychiatry
ISSN
1472-1465 (Electronic)
ISSN-L
0007-1250
Publication state
Published
Issued date
08/2011
Peer-reviewed
Oui
Volume
199
Number
2
Pages
126-131
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Evidence suggests a role for oestrogen in depression but the involvement of oestrogen receptor polymorphisms remains unknown.
To determine the association between oestrogen receptor polymorphisms and late-life depression and the modifying effect of hormone treatment.
Depression was assessed using the Mini-International Neuropsychiatric Interview, according to DSM-IV criteria and the Centre for Epidemiologic Studies - Depression Scale. The association between oestrogen receptor α and β (ER-α and ER-β) polymorphisms with severe depression was examined in 6017 community-dwelling elderly people using multivariate logistic regression.
In women, the ER-α rs2234693 and rs9340799 polymorphisms were significantly associated with the risk of late-life depression. The A allele of ER-β rs1256049 increased the risk of depression, but only for non-current users of hormone treatment. In men, only the ER-β rs4986938 polymorphism showed a weak association with depression risk.
Oestrogen receptor polymorphisms are associated with severe late-life depression risk in women only.
To determine the association between oestrogen receptor polymorphisms and late-life depression and the modifying effect of hormone treatment.
Depression was assessed using the Mini-International Neuropsychiatric Interview, according to DSM-IV criteria and the Centre for Epidemiologic Studies - Depression Scale. The association between oestrogen receptor α and β (ER-α and ER-β) polymorphisms with severe depression was examined in 6017 community-dwelling elderly people using multivariate logistic regression.
In women, the ER-α rs2234693 and rs9340799 polymorphisms were significantly associated with the risk of late-life depression. The A allele of ER-β rs1256049 increased the risk of depression, but only for non-current users of hormone treatment. In men, only the ER-β rs4986938 polymorphism showed a weak association with depression risk.
Oestrogen receptor polymorphisms are associated with severe late-life depression risk in women only.
Keywords
Age Factors, Aged, Aged, 80 and over, Alleles, Depressive Disorder, Major/epidemiology, Depressive Disorder, Major/genetics, Effect Modifier, Epidemiologic, Estrogen Replacement Therapy, Female, Gene Frequency, Genetic Predisposition to Disease/epidemiology, Genotype, Humans, Logistic Models, Longitudinal Studies, Male, Multivariate Analysis, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Postmenopause/psychology, Psychiatric Status Rating Scales, Receptors, Estrogen/genetics
Pubmed
Web of science
Open Access
Yes
Create date
22/08/2024 21:51
Last modification date
23/08/2024 9:34
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