Neurobiology of suicide: do biomarkers exist?

Détails

ID Serval
serval:BIB_8CCC8D1AE316
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Neurobiology of suicide: do biomarkers exist?
Périodique
International Journal of Legal Medicine
Auteur(s)
Costanza A., D'Orta I., Perroud N., Burkhardt S., Malafosse A., Mangin P., La Harpe R.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
128
Numéro
1
Pages
73-82
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish Document Type: Review
Résumé
Clinical risk factors have a low predictive value on suicide. This may explain the increasing interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. This review aims to present the current neurobiological findings that have been shown to be implicated in suicide completers and to discuss how postmortem studies may be useful in characterizing these individuals. Data on the role of the main neurobiological systems in suicidality, such as the neurotransmitter families, hypothalamic-pituitary-adrenal axis, neurotrophic factors, and polyamines, are exposed at the different biochemical, genetic, and epigenetic levels. Some neuroanatomic and neuropathological aspects as well as their in vivo morphological and functional neuroimaging correlates are also described. Except for the serotoninergic system, particularly with respect to the polymorphism of the gene coding for the serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor, data did not converge to produce a univocal consensus. The possible limitations of currently published studies are discussed, as well as the scope for long-term prospective studies.
Pubmed
Web of science
Création de la notice
24/01/2014 19:38
Dernière modification de la notice
03/03/2018 19:14
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