Myocarditis of mixed connective tissue disease: favourable outcome after intravenous pulsed cyclophosphamide
Details
Serval ID
serval:BIB_8CCC338BC327
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Myocarditis of mixed connective tissue disease: favourable outcome after intravenous pulsed cyclophosphamide
Journal
Clinical Rheumatology
ISSN
0770-3198 (Print)
Publication state
Published
Issued date
1999
Volume
18
Number
1
Pages
85-7
Notes
Case Reports
Journal Article
Journal Article
Abstract
A 30-year-old woman with mixed connective tissue disease was admitted with Wernicke's aphasia and progressive dyspnoea with chest pain. Multiple brain infarcts on a computed tomographic scan were compatible with a thromboembolic aetiology. Echocardiography showed marked hypokinesia of the posterior wall, biventricular dilatation and a decreased left-ventricle ejection fraction (40%). A diagnosis of myocarditis was made on myocardial biopsies disclosing interstitial lymphocytic infiltrates and myocardial fibre necrosis. A treatment with steroids and monthly pulsed cyclophosphamide was introduced. The heart function rapidly improved as assessed by a left-ventricle ejection fraction of 55% and remained stable 17 months thereafter.
Keywords
Adult
Biopsy
Cyclophosphamide/*administration & dosage
Diagnosis, Differential
Echocardiography, Doppler
Female
Follow-Up Studies
Heart Ventricles/pathology/physiopathology/ultrasonography
Humans
Immunosuppressive Agents/*administration & dosage
Injections, Intravenous
Mixed Connective Tissue Disease/*complications/diagnosis/drug therapy
Myocarditis/diagnosis/drug therapy/*etiology
Stroke Volume
Tomography, X-Ray Computed
Pubmed
Web of science
Create date
28/01/2008 9:48
Last modification date
20/08/2019 14:51