Myocarditis of mixed connective tissue disease: favourable outcome after intravenous pulsed cyclophosphamide

Détails

ID Serval
serval:BIB_8CCC338BC327
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Myocarditis of mixed connective tissue disease: favourable outcome after intravenous pulsed cyclophosphamide
Périodique
Clinical Rheumatology
Auteur(s)
Hammann  C., Genton  C. Y., Delabays  A., Bischoff Delaloye  A., Bogousslavsky  J., Spertini  F.
ISSN
0770-3198 (Print)
Statut éditorial
Publié
Date de publication
1999
Volume
18
Numéro
1
Pages
85-7
Notes
Case Reports
Journal Article
Résumé
A 30-year-old woman with mixed connective tissue disease was admitted with Wernicke's aphasia and progressive dyspnoea with chest pain. Multiple brain infarcts on a computed tomographic scan were compatible with a thromboembolic aetiology. Echocardiography showed marked hypokinesia of the posterior wall, biventricular dilatation and a decreased left-ventricle ejection fraction (40%). A diagnosis of myocarditis was made on myocardial biopsies disclosing interstitial lymphocytic infiltrates and myocardial fibre necrosis. A treatment with steroids and monthly pulsed cyclophosphamide was introduced. The heart function rapidly improved as assessed by a left-ventricle ejection fraction of 55% and remained stable 17 months thereafter.
Mots-clé
Adult Biopsy Cyclophosphamide/*administration & dosage Diagnosis, Differential Echocardiography, Doppler Female Follow-Up Studies Heart Ventricles/pathology/physiopathology/ultrasonography Humans Immunosuppressive Agents/*administration & dosage Injections, Intravenous Mixed Connective Tissue Disease/*complications/diagnosis/drug therapy Myocarditis/diagnosis/drug therapy/*etiology Stroke Volume Tomography, X-Ray Computed
Pubmed
Web of science
Création de la notice
28/01/2008 10:48
Dernière modification de la notice
03/03/2018 19:14
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