Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Myocarditis of mixed connective tissue disease: favourable outcome after intravenous pulsed cyclophosphamide
A 30-year-old woman with mixed connective tissue disease was admitted with Wernicke's aphasia and progressive dyspnoea with chest pain. Multiple brain infarcts on a computed tomographic scan were compatible with a thromboembolic aetiology. Echocardiography showed marked hypokinesia of the posterior wall, biventricular dilatation and a decreased left-ventricle ejection fraction (40%). A diagnosis of myocarditis was made on myocardial biopsies disclosing interstitial lymphocytic infiltrates and myocardial fibre necrosis. A treatment with steroids and monthly pulsed cyclophosphamide was introduced. The heart function rapidly improved as assessed by a left-ventricle ejection fraction of 55% and remained stable 17 months thereafter.
Adult Biopsy Cyclophosphamide/*administration & dosage Diagnosis, Differential Echocardiography, Doppler Female Follow-Up Studies Heart Ventricles/pathology/physiopathology/ultrasonography Humans Immunosuppressive Agents/*administration & dosage Injections, Intravenous Mixed Connective Tissue Disease/*complications/diagnosis/drug therapy Myocarditis/diagnosis/drug therapy/*etiology Stroke Volume Tomography, X-Ray Computed
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