Somatosensory motor bodily representation cortical thinning in Tourette : effects of tic severity, age and gender

Détails

ID Serval
serval:BIB_8CB7F7140149
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Somatosensory motor bodily representation cortical thinning in Tourette : effects of tic severity, age and gender
Périodique
Cortex
Auteur(s)
Fahim Cherine, Yoon Uicheul, Das Samir, Lyttelton Oliver, Chen John, Arnaoutelis Rozie, Rouleau Guy, Sandor Paul, Frey Kirk, Brandner Catherine, Evans Alan C.
ISSN
0010-9452
Statut éditorial
Publié
Date de publication
07/2009
Peer-reviewed
Oui
Pages
1-11
Langue
anglais
Résumé
Introduction: Tourette syndrome (TS) implicates the disinhibition of the cortico-striatal-thalamic-cortical circuitry (CSTC). Previous studies used a volumetric approach to investigate this circuitry with inconsistent findings. Cortical thickness may represent a more reliable measure than volume due to the low variability in the cytoarchitectural structure of the grey matter.
Methods: 66 magnetic resonance imaging scans were acquired from 34 TS (age range 10-25, mean 17.19±4.1) and 32 normal controls (NC) (age range 10-20, mean 16.33±3.56). Brain morphology was assessed using the fully automated Civet pipeline at the Montreal Neurological Institute.
Results: We report (1) significant cortical thinning in the fronto-parietal and somatosensory-motor cortices in TS relative to NC (p<0.05); (2) TS boys showed thinner cortex relative to TS girls in the fronto-parietal cortical regions (p<0.05); (3) significant decrease in the fronto-parietal mean cortical thickness in TS with age relative to NC and in the pre-central cortex in TS boys relative to TS girls; (4) significant negative correlations between tic severity and the somatosensory-motor cortical thickness.
Conclusions: TS revealed important thinning in brain regions particularly involved in the somatosensory/motor bodily representations which may play an important role in tics. Our findings are in agreement with Leckman et al. (1991) hypothesis stating that facial tics would be associated with dysfunction in an orofacial subset of the motor circuit, eye blinking with the occulo-motor circuit, whereas lack of inhibition to a dysfunction in the prefrontal cortex. Gender and age differences may reflect differential etiological factors, which have significant clinical relevance in TS and should be considered in developing and using diagnostic and therapeutic interventions.
Mots-clé
Tourette syndrome, cortical thickness, neuroimaging, magnetic resonance imaging, gender, age
Création de la notice
24/06/2009 14:28
Dernière modification de la notice
03/03/2018 19:14
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