A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes.

Détails

ID Serval
serval:BIB_8C9D95A0BEF9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes.
Périodique
Advances in colloid and interface science
Auteur(s)
Lee E.Y., Lee C.K., Schmidt N.W., Jin F., Lande R., Curk T., Frenkel D., Dobnikar J., Gilliet M., Wong GCL
ISSN
1873-3727 (Electronic)
ISSN-L
0001-8686
Statut éditorial
Publié
Date de publication
06/2016
Peer-reviewed
Oui
Volume
232
Pages
17-24
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
Publication Status: ppublish
Résumé
We examine how the interferon production of plasmacytoid dendritic cells is amplified by the self-assembly of liquid-crystalline antimicrobial peptide/DNA complexes. These specialized dendritic cells are important for host defense because they quickly release large quantities of type I interferons in response to infection. However, their aberrant activation is also correlated with autoimmune diseases such as psoriasis and lupus. In this review, we will describe how polyelectrolyte self-assembly and the statistical mechanics of multivalent interactions contribute to this process. In a more general compass, we provide an interesting conceptual corrective to the common notion in molecular biology of a dichotomy between specific interactions and non-specific interactions, and show examples where one can construct exquisitely specific interactions using non-specific interactions.

Mots-clé
Animals, Autoimmune Diseases, DNA, Dendritic Cells/chemistry, Dendritic Cells/immunology, Humans, Immunity, Cellular, Interferon Type I, Innate immunity, Multivalency, Polyelectrolytes, SAXS, Statistical mechanics, TLR9
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/03/2016 19:05
Dernière modification de la notice
08/05/2019 21:46
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