A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes.
Details
Serval ID
serval:BIB_8C9D95A0BEF9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes.
Journal
Advances in colloid and interface science
ISSN
1873-3727 (Electronic)
ISSN-L
0001-8686
Publication state
Published
Issued date
06/2016
Peer-reviewed
Oui
Volume
232
Pages
17-24
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
We examine how the interferon production of plasmacytoid dendritic cells is amplified by the self-assembly of liquid-crystalline antimicrobial peptide/DNA complexes. These specialized dendritic cells are important for host defense because they quickly release large quantities of type I interferons in response to infection. However, their aberrant activation is also correlated with autoimmune diseases such as psoriasis and lupus. In this review, we will describe how polyelectrolyte self-assembly and the statistical mechanics of multivalent interactions contribute to this process. In a more general compass, we provide an interesting conceptual corrective to the common notion in molecular biology of a dichotomy between specific interactions and non-specific interactions, and show examples where one can construct exquisitely specific interactions using non-specific interactions.
Keywords
Animals, Autoimmune Diseases, DNA, Dendritic Cells/chemistry, Dendritic Cells/immunology, Humans, Immunity, Cellular, Interferon Type I, Innate immunity, Multivalency, Polyelectrolytes, SAXS, Statistical mechanics, TLR9
Pubmed
Web of science
Open Access
Yes
Create date
10/03/2016 18:05
Last modification date
20/08/2019 14:50