Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Protein C replacement in severe meningococcemia: rationale and clinical experience.
Clinical Infectious Diseases
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review Publication Status: ppublish
Severe meningococcemia, which is associated with hemodynamic instability, purpura fulminans and disseminated intravascular coagulation, still has a high mortality rate, and patients who survive are often left invalids because of amputations and organ failure. Clinical studies have shown that levels of protein C are markedly decreased in patients with severe meningococcemia and that the extent of the decrease correlates with a negative clinical outcome. There is a growing body of data demonstrating that activated protein C, in addition to being an anticoagulant, is also a physiologically relevant modulator of the inflammatory response. The dual function of protein C may be relevant to the treatment of individuals with severe meningococcal sepsis. In the present review we give a basic overview of the protein C pathway and its anticoagulant activity, and we summarize experimental data showing that activated protein C replacement therapy clearly reduces the mortality rate for fulminant meningococcemia.
Animals, Anti-Inflammatory Agents, Non-Steroidal/metabolism, Anti-Inflammatory Agents, Non-Steroidal/therapeutic use, Anticoagulants/metabolism, Anticoagulants/therapeutic use, Bacteremia/drug therapy, Bacteremia/immunology, Blood Coagulation, Humans, Meningococcal Infections/drug therapy, Meningococcal Infections/immunology, Protein C/metabolism, Protein C/physiology
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