Effects of glucose and amino acid infusion on glucose turnover in insulin-resistant obese and type II diabetic patients

Détails

ID Serval
serval:BIB_8C85192153B9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effects of glucose and amino acid infusion on glucose turnover in insulin-resistant obese and type II diabetic patients
Périodique
Metabolism: Clinical and Experimental
Auteur(s)
Tappy  L., Acheson  K., Normand  S., Pachiaudi  C., Jequier  E., Riou  J. P.
ISSN
0026-0495 (Print)
Statut éditorial
Publié
Date de publication
04/1994
Volume
43
Numéro
4
Pages
428-34
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
Glucose turnover was assessed from [6,6-2H]glucose and [U-13C]glucose dilution analysis in six lean nondiabetic subjects, six obese patients with normal glucose tolerance, and six obese patients with non-insulin-dependent diabetes mellitus (NIDDM) during sequential infusions of glucose (13.9 mumol/kg fat-free mass [FFM]/min) and glucose+amino acid (4.2 mg/kg FFM/min). Cori cycle activity was assessed from the difference between glucose turnover obtained from [6,6-2H]glucose and [U-13C]glucose. During infusion of glucose alone, total glucose turnover was increased by 70% in obese NIDDM patients. Amino acid infusion decreased glucose concentrations by 0.8, 0.5, and 1.8 mmol/L in controls, obese patients, and NIDDM patients, respectively. This decrease in glycemia occurred despite an increase in glucose turnover in lean and obese nondiabetic subjects, and was due to an increased metabolic clearance rate (MCR) of glucose. In NIDDM patients the MCR of glucose was unchanged, and the decrease in glycemia was explained by a diminution in hepatic glucose output. Glucose turnover obtained by [6.6-2H] dilution analysis exceeded significantly the values obtained by dilution analysis in obese subjects and obese NIDDM patients, but not in controls. This indicates an increased Cori cycle activity in these patients.
Mots-clé
Adolescent Adult Aged Amino Acids/*pharmacology Blood Glucose/*metabolism Diabetes Mellitus, Type 2/complications/*metabolism Female Glucose/*metabolism/*pharmacology Glycosuria/metabolism Humans Insulin Resistance Male Middle Aged Obesity/complications/*metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
03/03/2018 19:13
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