Various human interferon alpha subclasses cross-react with common receptors: their binding affinities correlate with their specific biological activities.

Détails

ID Serval
serval:BIB_8C26BCAFB500
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Various human interferon alpha subclasses cross-react with common receptors: their binding affinities correlate with their specific biological activities.
Périodique
Virology
Auteur(s)
Aguet M., Gröbke M., Dreiding P.
ISSN
0042-6822 (Print)
ISSN-L
0042-6822
Statut éditorial
Publié
Date de publication
1984
Volume
132
Numéro
1
Pages
211-216
Langue
anglais
Résumé
Seven different human interferon (IFN) alpha subtypes were compared with regard to competitive inhibition of specific high-affinity binding of 125I-labeled IFN alpha-2 to human and bovine cells. All IFNs tested (alpha-1, -2, -4, -5, -6, -7, -8) competed for common binding sites. Marked differences in the binding affinities were observed between IFN alpha-1 and IFN alpha-2. The binding affinities of the various subtypes correlated with the respective specific biological activities determined in an antiviral assay. These observations suggest that at least some biological effects of IFNs are initiated by receptor activation and depend quantitatively on the degree of receptor saturation.
Mots-clé
Animals, Binding, Competitive, Cattle, Female, Humans, Interferon Type I/metabolism, Pregnancy, Receptors, Cell Surface/metabolism, Receptors, Interferon
Pubmed
Web of science
Création de la notice
28/01/2008 12:36
Dernière modification de la notice
03/03/2018 19:13
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