Melanoma and innate immunity--aActive inflammation or just erroneous attraction? Melanoma as the source of leukocyte-attracting chemokines.

Détails

ID Serval
serval:BIB_8C228BBB0798
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Melanoma and innate immunity--aActive inflammation or just erroneous attraction? Melanoma as the source of leukocyte-attracting chemokines.
Périodique
Seminars in Cancer Biology
Auteur(s)
Navarini-Meury A.A., Conrad C.
ISSN
1096-3650 (Electronic)
ISSN-L
1044-579X
Statut éditorial
Publié
Date de publication
2009
Volume
19
Numéro
2
Pages
84-91
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
Unwanted growth breeds response--in the garden as well as in the tumor microenvironment. Innate immune cells mediate the earliest responses against melanoma or its precursors. However, the actual benefit by those cellular efforts is questionable. Why can early melanoma lesions actually develop in the face of rapid innate responses, and why is neutrophil- and macrophage-attracting chemokine secretion observed in melanoma? A surprisingly similar choice of chemokine receptors and chemokines are present in both innate immune cells and melanoma. Here we focus on analogies and differences between the two. Melanoma cell clusters show active chemokine signalling, with mostly tumor growth-enhancing and leukocyte-attracting effects. However, infiltrating leukocytes have only weak tumoricidal effects. Therefore, the observed leukocyte infiltration in melanoma might be at least in part an epiphenomenon of neoplastic self-stimulation rather than a full-fledged innate anti-tumor immune response.
Mots-clé
Animals, Chemokines/immunology, Humans, Immunity, Innate, Inflammation/immunology, Leukocytes/immunology, Melanoma/immunology
Pubmed
Web of science
Création de la notice
26/03/2012 11:28
Dernière modification de la notice
20/08/2019 15:50
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