Inaugural Symptom(s) in Parkinsonism (PS) of Various Etiologies

Détails

ID Serval
serval:BIB_8C19B6D89721
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
Inaugural Symptom(s) in Parkinsonism (PS) of Various Etiologies
Titre de la conférence
American Academy of Neurology 50th Annual Meeting Program
Auteur(s)
Ghika  J, Francois  V, Albanese  A
Adresse
Minneapolis, MN; April 25-May 2, 1998
ISBN
0028-3878
ISSN-L
0028-3878
Statut éditorial
Publié
Date de publication
1998
Volume
50
Série
Neurology
Pages
A385-A386
Langue
anglais
Notes
Meeting Abstract: P06.033
Résumé
OBJECTIVE: To study inaugural symptom(s) in parkisonism (PS) of various etiologies from the Lausanne Movement Disorders Registry (LMDR).
BACKGROUND: Inaugural symptom(s) may provide some information about early diagnosis in PS.
DESIGN/METHODS: Prospective study of inaugural symptom(s)(spontaneous report and suggested) in clinically-diagnosed PS.
RESULTS: 1066 patients with PS from the LMDR were studied: 333 Parkinson's diseases (PD) (31%); 215 multiple system atrophies (MSA)(20%)[165 nigrostriate degenerations (NSD), 10 Shy- Drager syndromes (SDS) and 40 olivo-ponto-cerebellar atrophies (OPCA)]; 204 PS and dementia (PDD) (19%); 61 progressive supranuclear palsies (PSP)(6%); 59 PS of various causes (PDV)(5%); 59 familial PS (F-PS)(5%); 53 drug-induced PS (DIP)(5%); 46 almost pure tremulous PD (T-PD) (4%); 20 cortico-baso-ganglionic degenerations (CBGD) (2%) and 16 early-onset PD (E-PD)(1%). Tremor was the most frequent initial symptom in PS (34%): 86 % in T-PD, 46% in PD, 40% in F-PD, 32% in PDD, but only second in SND (21%) and E-PD (25%) and less frequent elsewhere. Inaugural gait symptoms (17%) were second in frequency, but first in OPCA (72%), PSP (46%), PDV (30%) and SND (24%) and second in PDD (14%). Initial slowness (17%), stiffness (8%), depression (5%), pain (5%), fatigue (4%), psychosis (4%), cognitive dysfunction (3%), dysautonomia (2%), micrographia (1%), amimia(1%)were less frequent. Obsessive traits (OT) were only found in PD (70%) and SND (20%). Sleep problems were initial in SDS only. Inaugural pain was first in E-PD (38%) and CBGD (30%), and inaugural psychosis in DIP (58%) and PDD(5%). Significant (p=0.05) correlations between initial symptoms and diagnosis were found for tremor in T-PD only, for gait in PSP, MSA (OPCA and SND), for slowness in E-PD and DIPD, for stiffness in F-PD and PD, for pain in E-PD (trend in CBGD), for dysautonomia in MSA (p<0.02 in SDS), for cognitive dysfunction in PDD, for dysarthria in PSP, for dystonia in E-PD(trend in F-PD), and for OT in PD and MSA.
CONCLUSIONS: Inaugural tremor, the major first symptom in PS has no significant correlation with any diagnosis except T-PD. Gait problems, the second most frequent inaugural symptom, are only significantly correlated with PSP. Initial pain, slowness, dystonia and micrographia had significant correlation with E-PD, inaugural dysarthria with PSP, cognitive dysfunction with PDD, psychosis with DIP and PDD and dysautonomia with MSA, especially SDS. OT were only found in PD and MSA.
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Création de la notice
11/12/2013 23:40
Dernière modification de la notice
03/03/2018 19:13
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