Association Between Lifetime Marijuana Use and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Details

Ressource 1Download: 5_26831916.pdf (911.59 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_8BF86269A7C1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association Between Lifetime Marijuana Use and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Journal
JAMA internal medicine
Author(s)
Auer R., Vittinghoff E., Yaffe K., Künzi A., Kertesz S.G., Levine D.A., Albanese E., Whitmer R.A., Jacobs D.R., Sidney S., Glymour M.M., Pletcher M.J.
ISSN
2168-6114 (Electronic)
ISSN-L
2168-6106
Publication state
Published
Issued date
03/2016
Peer-reviewed
Oui
Volume
176
Number
3
Pages
352-361
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Marijuana use is increasingly common in the United States. It is unclear whether it has long-term effects on memory and other domains of cognitive function.
To study the association between cumulative lifetime exposure to marijuana use and cognitive performance in middle age.
We used data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a cohort of 5115 black and white men and women aged 18 to 30 years at baseline from March 25, 1985, to June 7, 1986 (year 0), and followed up over 25 years from June 7, 1986, to August 31, 2011, to estimate cumulative years of exposure to marijuana (1 year = 365 days of marijuana use) using repeated measures and to assess associations with cognitive function at year 25. Linear regression was used to adjust for demographic factors, cardiovascular risk factors, tobacco smoking, use of alcohol and illicit drugs, physical activity, depression, and results of the mirror star tracing test (a measure of cognitive function) at year 2. Data analysis was conducted from June 7, 1986, to August 31, 2011.
Three domains of cognitive function were assessed at year 25 using the Rey Auditory Verbal Learning Test (verbal memory), the Digit Symbol Substitution Test (processing speed), and the Stroop Interference Test (executive function).
Among 3385 participants with cognitive function measurements at the year 25 visit, 2852 (84.3%) reported past marijuana use, but only 392 (11.6%) continued to use marijuana into middle age. Current use of marijuana was associated with worse verbal memory and processing speed; cumulative lifetime exposure was associated with worse performance in all 3 domains of cognitive function. After excluding current users and adjusting for potential confounders, cumulative lifetime exposure to marijuana remained significantly associated with worse verbal memory. For each 5 years of past exposure, verbal memory was 0.13 standardized units lower (95% CI, -0.24 to -0.02; P = .02), corresponding to a mean of 1 of 2 participants remembering 1 word fewer from a list of 15 words for every 5 years of use. After adjustment, we found no associations with lower executive function (-0.03 [95% CI, -0.12 to 0.07]; P = .56) or processing speed (-0.04 [95% CI, -0.16 to 0.08]; P = .51).
Past exposure to marijuana is associated with worse verbal memory but does not appear to affect other domains of cognitive function.
Keywords
Adult, Cannabis/adverse effects, Cognition, Coronary Artery Disease/epidemiology, Coronary Artery Disease/etiology, Drug Users/psychology, Drug Users/statistics & numerical data, Executive Function, Female, Humans, Longitudinal Studies, Male, Memory, Middle Aged, Risk Factors, United States/epidemiology, Verbal Learning, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
16/02/2016 17:30
Last modification date
20/08/2019 14:50
Usage data