Article: article from journal or magazin.
The biochemistry of drug metabolism : an introduction : part 6, Inter-individual factors affecting drug metabolism.
Chemistry and Biodiversity
This review is part of a series of review articles on the metabolism of drugs and other xenobiotics published in Chemistry & Biodiversity. After a thorough discussion of metabolic reactions and their enzymes, this article focuses on genetically determined differences in drug and xenobiotic metabolism. After a short introduction on the causes for genetic differences, the first focus is on species differences in drug and xenobiotic metabolism. A major chapter is then dedicated to clinically relevant genetic polymorphisms in human drug metabolism and resultant ethnic differences. The last two chapters deal with sex-dependent differences in drug metabolism and personalized pharmacotherapy related to inter-individual differences in drug metabolism.
Animals, Cytochrome P-450 Enzyme System/chemistry, Cytochrome P-450 Enzyme System/genetics, Enzymes/genetics, Enzymes/metabolism, Genotype, Humans, Mice, Mutation, Oxidoreductases/chemistry, Oxidoreductases/genetics, Pharmaceutical Preparations/chemistry, Pharmaceutical Preparations/metabolism, Pharmacokinetics, Polymorphism, Genetic, Rats, Sex Factors, Species Specificity
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