The biochemistry of drug metabolism : an introduction : part 6, Inter-individual factors affecting drug metabolism.

Détails

ID Serval
serval:BIB_8BC6A79346DB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The biochemistry of drug metabolism : an introduction : part 6, Inter-individual factors affecting drug metabolism.
Périodique
Chemistry and Biodiversity
Auteur(s)
Krämer S.D., Testa B.
ISSN
1612-1872
Statut éditorial
Publié
Date de publication
2008
Volume
5
Numéro
12
Pages
2465-2578
Langue
anglais
Résumé
This review is part of a series of review articles on the metabolism of drugs and other xenobiotics published in Chemistry & Biodiversity. After a thorough discussion of metabolic reactions and their enzymes, this article focuses on genetically determined differences in drug and xenobiotic metabolism. After a short introduction on the causes for genetic differences, the first focus is on species differences in drug and xenobiotic metabolism. A major chapter is then dedicated to clinically relevant genetic polymorphisms in human drug metabolism and resultant ethnic differences. The last two chapters deal with sex-dependent differences in drug metabolism and personalized pharmacotherapy related to inter-individual differences in drug metabolism.
Mots-clé
Animals, Cytochrome P-450 Enzyme System/chemistry, Cytochrome P-450 Enzyme System/genetics, Enzymes/genetics, Enzymes/metabolism, Genotype, Humans, Mice, Mutation, Oxidoreductases/chemistry, Oxidoreductases/genetics, Pharmaceutical Preparations/chemistry, Pharmaceutical Preparations/metabolism, Pharmacokinetics, Polymorphism, Genetic, Rats, Sex Factors, Species Specificity
Pubmed
Web of science
Création de la notice
15/10/2009 9:42
Dernière modification de la notice
03/03/2018 19:12
Données d'usage