Successful conservative treatment of massive choroidal relapse in 2 retinoblastoma patients monitored by ultrasound biomicroscopy and/or spectral domain optic coherence tomography.

Détails

ID Serval
serval:BIB_8BC0E40FE518
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Successful conservative treatment of massive choroidal relapse in 2 retinoblastoma patients monitored by ultrasound biomicroscopy and/or spectral domain optic coherence tomography.
Périodique
Ophthalmic genetics
Auteur(s)
Stathopoulos C., Gaillard M.C., Puccinelli F., Maeder P., Hadjistilianou D., Beck-Popovic M., Munier F.L.
ISSN
1744-5094 (Electronic)
ISSN-L
1381-6810
Statut éditorial
Publié
Date de publication
04/2018
Peer-reviewed
Oui
Volume
39
Numéro
2
Pages
242-246
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
To report the occurrence and management of secondary choroidal infiltration in two retinoblastoma (rb) patients.
Fundus examination and imaging with spectral domain optical coherence tomography (SD-OCT), B-scan ultrasonography (B-scan), and ultrasound biomicroscopy (UBM).
Case 1: A 19-month-old girl with multifocal unilateral group B rb pretreated with intravenous chemotherapy (IVC) was referred for further management. At 3.5 years of age, routine 3-Tesla magnetic resonance imaging (3T-MRI) revealed an asymptomatic pinealoblastoma that underwent resection and adjuvant intensive IVC. Concomitant ophthalmic follow-up revealed a recurrence 8.3 × 2.8 mm at the posterior pole nasally to the optic disc on B-scan, localized within the choroid on SD-OCT and 3T-MRI. With high dose IVC ongoing, total regression of the choroidal mass was confirmed on SD-OCT already after 3 weeks. At 6-month follow-up, choroidal and pineal tumors were in complete remission. Sadly, the child died of intravascular disseminated coagulation-like disease after the 5th IVC. Case 2: A heavily pretreated 20-month-old girl with bilateral rb was referred for persistent vitreous seeding in her remaining eye (OD). Three months after intravitreal chemotherapy and chemothermotherapy, a hemorrhagic mass was observed inferior to the primary tumor. Two weeks later, an underlying peripheral choroidal mass 16 × 6 mm was documented by UBM and confirmed by 3T-MRI. Complete resolution was achieved 3 weeks after combined intra-arterial chemotherapy (IAC) of melphalan-topotecan. No recurrence or metastasis was observed at 34-month follow-up.
Isolated massive choroidal invasion can be treated conservatively with IVC or IAC in selected cases. SD-OCT, UBM, and B-scan ultrasonography are instrumental in the detection and follow-up of choroidal lesions.
Mots-clé
Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Choroid Neoplasms/diagnostic imaging, Choroid Neoplasms/drug therapy, Choroid Neoplasms/secondary, Conservative Treatment, Fatal Outcome, Female, Fluorescein Angiography, Humans, Infant, Infusions, Intra-Arterial, Magnetic Resonance Imaging, Melphalan/administration & dosage, Microscopy, Acoustic, Neoplasm Recurrence, Local/diagnostic imaging, Neoplasm Recurrence, Local/drug therapy, Neoplasm Recurrence, Local/pathology, Retinal Neoplasms/diagnostic imaging, Retinal Neoplasms/drug therapy, Retinal Neoplasms/pathology, Retinoblastoma/diagnostic imaging, Retinoblastoma/drug therapy, Retinoblastoma/secondary, Tomography, Optical Coherence, Topotecan/administration & dosage, Choroid, intra-arterial chemotherapy, intravenous chemotherapy, omography, retinoblastoma, spectral domain optic coherence, ultrasound biomicroscopy
Pubmed
Web of science
Création de la notice
14/11/2017 9:41
Dernière modification de la notice
20/08/2019 14:50
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