Instantaneous coronary collateral function during supine bicycle exercise.

Détails

ID Serval
serval:BIB_8B8BD4812E94
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Instantaneous coronary collateral function during supine bicycle exercise.
Périodique
European heart journal
Auteur(s)
Togni M., Gloekler S., Meier P., de Marchi S.F., Rutz T., Steck H., Traupe T., Seiler C.
ISSN
1522-9645 (Electronic)
ISSN-L
0195-668X
Statut éditorial
Publié
Date de publication
09/2010
Peer-reviewed
Oui
Volume
31
Numéro
17
Pages
2148-2155
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The instantaneous response of the collateral circulation to isometric physical exercise in patients with non-occlusive coronary artery disease (CAD) is not known.
Thirty patients (age 59 +/- 9 years) undergoing percutaneous coronary intervention because of stable CAD were included in the study. Collateral function was determined before and during the last minute of a 6 min protocol of supine bicycle exercise during radial artery access coronary angiography. Collateral flow index (CFI, no unit) was determined as the ratio of mean distal coronary occlusive to mean aortic pressure both subtracted by central venous pressure. To avoid confounding due to recruitment of coronary collaterals by repetitive balloon occlusions, patients were randomly assigned to a group 'rest first' with CFI measurement during rest followed by CFI during exercise, and to a group 'exercise first' with antecedent CFI measurement during exercise before CFI at rest. Simultaneously, coronary collateral conductance (occlusive myocardial blood flow per aorto-coronary pressure drop) was determined by myocardial contrast echocardiography in the last 10 consecutive patients. Overall, CFI increased from 0.168 +/- 0.118 at rest to 0.262 +/- 0.166 during exercise (P = 0.0002). The exercise-induced change in CFI did not differ statistically in the two study groups. Exercise-induced CFI reserve (CFI during exercise divided by CFI at rest) was 2.2 +/- 1.8. Overall, rest to peak bicycle exercise change of coronary collateral conductance was from 0.010 +/- 0.010 to 1.109 +/- 0.139 mL/min/100 mmHg (P < 0.0001); the respective change was similar in both groups.
In patients with non-occlusive CAD, collateral flow instantaneously doubles during supine bicycle exercise as compared with the resting state. ClinicalTrials.gov Identifier: NCT00947050.

Mots-clé
Aged, Angina Pectoris/physiopathology, Balloon Occlusion, Cardiac Catheterization, Collateral Circulation/physiology, Coronary Angiography, Coronary Artery Disease/physiopathology, Coronary Artery Disease/therapy, Coronary Circulation/physiology, Electrocardiography, Exercise/physiology, Exercise Test, Female, Hemodynamics/physiology, Humans, Male, Middle Aged
Pubmed
Web of science
Création de la notice
07/08/2017 12:19
Dernière modification de la notice
03/03/2018 19:12
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