The Sleep/Wake Cycle is Directly Modulated by Changes in Energy Balance.

Details

Serval ID
serval:BIB_8B4F927DFD1B
Type
Article: article from journal or magazin.
Collection
Publications
Title
The Sleep/Wake Cycle is Directly Modulated by Changes in Energy Balance.
Journal
SLEEP
Author(s)
Collet Tinh-Hai, van der Klaauw Agatha A, Henning Elana, Keogh Julia M, Suddaby Diane, Dachi Sekesai V, Dunbar Sle, Kelway Sarah, Dickson Suzanne L, Farooqi I Sadaf, Schmid Sebastian M
ISSN
0161-8105
Publication state
Published
Issued date
09/2016
Peer-reviewed
Oui
Volume
39
Number
9
Pages
1691-1700
Language
english
Abstract
STUDY OBJECTIVES:The rise in obesity has been paralleled by a decline in sleep duration in epidemiological studies. However, the potential mechanisms linking energy balance and the sleep/wake cycle are not well understood. We aimed to examine the effects of manipulating energy balance on the sleep/wake cycle.
METHODS:Twelve healthy normal weight men were housed in a clinical research facility and studied at three time points: baseline, after energy balance was disrupted by 2 days of caloric restriction to 10% of energy requirements, and after energy balance was restored by 2 days of ad libitum/free feeding. Sleep architecture, duration of sleep stages, and sleep-associated respiratory parameters were measured by polysomnography.
RESULTS:Two days of caloric restriction significantly increased the duration of deep (stage 4) sleep (16.8% to 21.7% of total sleep time; P = 0.03); an effect which was entirely reversed upon free feeding (P = 0.01). Although the apnea-hypopnea index stayed within the reference range (<5 events per hour), it decreased significantly from caloric restriction to free feeding (P = 0.03). Caloric restriction was associated with a marked fall in leptin (P < 0.001) and insulin levels (P = 0.002). The fall in orexin levels from baseline to caloric restriction correlated positively with duration of stage 4 sleep (Spearman rho = 0.83, P = 0.01) and negatively with the number of awakenings in caloric restriction (Spearman rho = 0.79, P = 0.01).
CONCLUSIONS:We demonstrate that changes in energy homeostasis directly and reversibly impact on the sleep/wake cycle. These findings provide a mechanistic framework for investigating the association between sleep duration and obesity risk.
Pubmed
Open Access
Yes
Create date
15/09/2017 16:23
Last modification date
20/08/2019 14:49
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