Gentamicin Exposure and Sensorineural Hearing Loss in Preterm Infants.

Détails

Ressource 1Télécharger: BIB_8AEAB3EBFFC4.P001.pdf (202.65 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_8AEAB3EBFFC4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Gentamicin Exposure and Sensorineural Hearing Loss in Preterm Infants.
Périodique
PloS one
Auteur(s)
Fuchs A., Zimmermann L., Bickle Graz M., Cherpillod J., Tolsa J.F., Buclin T., Giannoni E.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
11
Numéro
7
Pages
e0158806
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
To evaluate the impact of gentamicin exposure on sensorineural hearing loss (SNHL) in very low birth weight (VLBW) infants.
Exposure to gentamicin was determined in infants born between 1993 and 2010 at a gestational age < 32 weeks and/or with a birthweight < 1500 g, who presented with SNHL during the first 5 years of life. For each case, we selected two controls matched for gender, gestational age, birthweight, and year of birth.
We identified 25 infants affected by SNHL, leading to an incidence of SNHL of 1.58% in our population of VLBW infants. The proportion of infants treated with gentamicin was 76% in the study group and 70% in controls (p = 0.78). The total cumulated dose of gentamicin administered did not differ between the study group (median 10.2 mg/kg, Q1-Q3 1.6-13.2) and the control group (median 7.9 mg/kg, Q1-Q3 0-12.8, p = 0.47). The median duration of gentamicin treatment was 3 days both in the study group and the control group (p = 0.58). Maximum predicted trough serum levels of gentamicin, cumulative area under the curve and gentamicin clearance were not different between cases and controls.
The impact of gentamicin on SNHL can be minimized with treatments of short duration, monitoring of blood levels and dose adjustment.

Mots-clé
Female, Gentamicins/administration & dosage, Gentamicins/adverse effects, Gentamicins/pharmacokinetics, Hearing Loss, Sensorineural/blood, Hearing Loss, Sensorineural/chemically induced, Hearing Loss, Sensorineural/epidemiology, Humans, Incidence, Infant Nutrition Disorders/blood, Infant Nutrition Disorders/chemically induced, Infant Nutrition Disorders/epidemiology, Infant, Newborn, Infant, Premature, Male, Retrospective Studies
Pubmed
Web of science
Création de la notice
14/07/2016 16:45
Dernière modification de la notice
01/03/2019 18:05
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