The Multicentre Acute ischemic stroke imaGIng and Clinical data (MAGIC) repository: rationale and blueprint.

Details

Serval ID
serval:BIB_8ADA954B262C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Multicentre Acute ischemic stroke imaGIng and Clinical data (MAGIC) repository: rationale and blueprint.
Journal
Frontiers in neuroinformatics
Author(s)
Baazaoui H., Engelter S.T., Gensicke H., Enz L.S., Psychogios M., Mutke M., Michel P., Strambo D., Salerno A., Marquering H.A., Nederkoorn P.J., Wali N., Tanadini-Lang S., Menze B., de la Rosa E., Yang K., De Marchis G.M., Dittrich T.D., Valletta F., Germann M., Cereda C.W., Marto J.P., Herzog L., Hirschi P., Kulcsar Z., Wegener S.
ISSN
1662-5196 (Print)
ISSN-L
1662-5196
Publication state
Published
Issued date
2024
Peer-reviewed
Oui
Volume
18
Pages
1508161
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The Multicentre Acute ischemic stroke imaGIng and Clinical data (MAGIC) repository is a collaboration established in 2024 by seven stroke centres in Europe. MAGIC consolidates clinical and radiological data from acute ischemic stroke (AIS) patients who underwent endovascular therapy, intravenous thrombolysis, a combination of both, or conservative management.
All centres ensure accuracy and completeness of the data. Only patients who did not refuse use of their routine data collected during or after their hospital stay are included in the repository. Approvals or waivers are obtained from the responsible ethics committees before data exchange. A formal data transfer agreement (DTA) is signed by all contributing centres. The centres then share their data, and files are stored centrally on a safe server at the University Hospital Zurich. There, patient identifiers are removed and images are algorithmically de-faced. De-identified structured clinical data are connected to the imaging data by a new identifier. Data are made available to participating centres which have entered into a DTA for stroke research projects.
Initially, MAGIC is set to comprise initial and first follow-up imaging of 2,500 AIS patients. Clinical data consist of a comprehensive set of patient characteristics and routine prehospital metrics, treatment and laboratory variables.
Our repository will support research by leveraging the entire range of routinely collected imaging and clinical data. This dataset reflects the current state of practice in stroke patient evaluation and management and will enable researchers to retrospectively study clinically relevant questions outside the scope of randomized controlled clinical trials. New centres are invited to join MAGIC if they meet the requirements outlined here. We aim to reach approximately 10,000 cases by 2026.
Keywords
collaboration, data sharing, ischemic stroke, neuroimaging, neurology, repository
Pubmed
Open Access
Yes
Create date
27/01/2025 11:21
Last modification date
28/01/2025 7:07
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