Circulating amino acid signature features urea cycle alterations associated with coronary artery disease.
Details
Serval ID
serval:BIB_8ACA9CE0EF20
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Circulating amino acid signature features urea cycle alterations associated with coronary artery disease.
Journal
Scientific reports
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
28/10/2024
Peer-reviewed
Oui
Volume
14
Number
1
Pages
25848
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Coronary artery disease (CAD) remains a leading cause of death worldwide and imposes a substantial socioeconomic burden on healthcare. Improving risk stratification in clinical practice could help to combat this burden. As amino acids are biologically active metabolites whose involvement in CAD remains largely unknown, this study investigated associations between circulating amino acid levels and CAD phenotypes. A high-coverage quantitative liquid chromatography-mass spectrometry approach was applied to acquire the serum amino acids profile of age- and sex-coarsened-matched patients with CAD (n = 46, 66.9 years, 74.7% male) and healthy individuals (n = 120, 67.4 years, 74.7% male) from the COmPLETE study. Multiple linear regressions were performed to investigate associations between amino acid levels and (a) the health status (CAD vs. healthy), (b) the number of affected coronary arteries, or (c) the left ventricular ejection fraction. Regressions were adjusted for age, sex, daily physical activity, sampling, and fasting time. Urea cycle amino acids (ornithine, citrulline, homocitrulline, aspartate, and arginine) were significantly and negatively associated with CAD, the number of affected coronary arteries, and the left ventricular ejection fraction. Lysine, histidine, and the glutamine/glutamate ratio were also significantly and negatively associated with the CAD phenotypes. Overall, patients with CAD displayed lower levels of urea cycle amino acids, highlighting a potential role for urea cycle amino acid profiling in cardiovascular risk stratification.Trial registrationThe study was registered on https://www.clinicaltrials.gov (NCT03986892) on June 5, 2019.
Keywords
Humans, Male, Female, Coronary Artery Disease/blood, Aged, Amino Acids/blood, Middle Aged, Urea/blood, Stroke Volume, Case-Control Studies, Biomarkers/blood, Amino acids, Coronary artery disease, Metabolic profiling, Metabolic signature, Urea cycle
Pubmed
Open Access
Yes
Create date
01/11/2024 13:15
Last modification date
02/11/2024 7:10