Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

Benyamin, B.; Esko, T.; Ried, J.S.; Radhakrishnan, A.; Vermeulen, S.H.; Traglia, M.; Gögele, M.; Anderson, D.; Broer, L.; Podmore, C.; Luan, J.; Kutalik, Z.; Sanna, S.; van der Meer, P.; Tanaka, T.; Wang, F.; Westra, H.J.; Franke, L.; Mihailov, E.; Milani, L.; Häldin, J.; Winkelmann, J.; Meitinger, T.; Thiery, J.; Peters, A.; Waldenberger, M.; Rendon, A.; Jolley, J.; Sambrook, J.; Kiemeney, L.A.; Sweep, F.C.; Sala, C.F.; Schwienbacher, C.; Pichler, I.; Hui, J.; Demirkan, A.; Isaacs, A.; Amin, N.; Steri, M.; Waeber, G.; Verweij, N.; Powell, J.E.; Nyholt, D.R.; Heath, A.C.; Madden, P.A.; Visscher, P.M.; Wright, M.J.; Montgomery, G.W.; Martin, N.G.; Hernandez, D.; Bandinelli, S.; van der Harst, P.; Uda, M.; Vollenweider, P.; Scott, R.A.; Langenberg, C.; Wareham, N.J.; van Duijn, C.; van Duijn, C.; Beilby, J.; Pramstaller, P.P.; Hicks, A.A.; Ouwehand, W.H.; Oexle, K.; Gieger, C.; Metspalu, A.; Camaschella, C.; Toniolo, D.; Swinkels, D.W.; Whitfield, J.B.

doi:10.1038/ncomms5926

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

Details

Download: 0_25352340_Postprint.pdf (639.89 [Ko])
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Secondary document(s)

Download: 0_25352340_Postprint.pdf (623.95 [Ko])
State: Public
Version: author

Serval ID

serval:BIB_8AB33C82AD70

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

Journal

Nature Communications

Author(s)

Benyamin B., Esko T., Ried J.S., Radhakrishnan A., Vermeulen S.H., Traglia M., Gögele M., Anderson D., Broer L., Podmore C., Luan J., Kutalik Z., Sanna S., van der Meer P., Tanaka T., Wang F., Westra H.J., Franke L., Mihailov E., Milani L., Häldin J., Winkelmann J., Meitinger T., Thiery J., Peters A., Waldenberger M., Rendon A., Jolley J., Sambrook J., Kiemeney L.A., Sweep F.C., Sala C.F., Schwienbacher C., Pichler I., Hui J., Demirkan A., Isaacs A., Amin N., Steri M., Waeber G., Verweij N., Powell J.E., Nyholt D.R., Heath A.C., Madden P.A., Visscher P.M., Wright M.J., Montgomery G.W., Martin N.G., Hernandez D., Bandinelli S., van der Harst P., Uda M., Vollenweider P., Scott R.A., Langenberg C., Wareham N.J., van Duijn C., van Duijn C., Beilby J., Pramstaller P.P., Hicks A.A., Ouwehand W.H., Oexle K., Gieger C., Metspalu A., Camaschella C., Toniolo D., Swinkels D.W., Whitfield J.B.

Working group(s)

InterAct Consortium

ISSN

2041-1723 (Electronic)

ISSN-L

2041-1723

Publication state

Published

Issued date

10/2014

Peer-reviewed

Oui

Volume

Number

Pages

4926

Language

english

Notes

Publication types: Journal Article Publication Status: epublish

Abstract

Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-significant (P<5 × 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14). SNPs at ARNTL, TF, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis. There is substantial overlap between our iron loci and loci affecting erythrocyte and lipid phenotypes. These results will facilitate investigation of the roles of iron in disease.

URN

urn:nbn:ch:serval-BIB_8AB33C82AD707

OAI-PMH

oai:serval.unil.ch:BIB_8AB33C82AD70

DOI

10.1038/ncomms5926

Pubmed

25352340

Web of science

000343934300001

Open Access

Yes