Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

Détails

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Etat: Serval
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Document(s) secondaire(s)
Télécharger: 0_25352340_Postprint.pdf (623.95 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_8AB33C82AD70
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
Périodique
Nature Communications
Auteur(s)
Benyamin B., Esko T., Ried J.S., Radhakrishnan A., Vermeulen S.H., Traglia M., Gögele M., Anderson D., Broer L., Podmore C., Luan J., Kutalik Z., Sanna S., van der Meer P., Tanaka T., Wang F., Westra H.J., Franke L., Mihailov E., Milani L., Häldin J., Winkelmann J., Meitinger T., Thiery J., Peters A., Waldenberger M., Rendon A., Jolley J., Sambrook J., Kiemeney L.A., Sweep F.C., Sala C.F., Schwienbacher C., Pichler I., Hui J., Demirkan A., Isaacs A., Amin N., Steri M., Waeber G., Verweij N., Powell J.E., Nyholt D.R., Heath A.C., Madden P.A., Visscher P.M., Wright M.J., Montgomery G.W., Martin N.G., Hernandez D., Bandinelli S., van der Harst P., Uda M., Vollenweider P., Scott R.A., Langenberg C., Wareham N.J., van Duijn C., van Duijn C., Beilby J., Pramstaller P.P., Hicks A.A., Ouwehand W.H., Oexle K., Gieger C., Metspalu A., Camaschella C., Toniolo D., Swinkels D.W., Whitfield J.B.
Collaborateur(s)
InterAct Consortium
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
10/2014
Peer-reviewed
Oui
Volume
5
Numéro
12
Pages
4926
Langue
anglais
Notes
Publication types: Journal Article Publication Status: epublish
Résumé
Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-significant (P<5 × 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14). SNPs at ARNTL, TF, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis. There is substantial overlap between our iron loci and loci affecting erythrocyte and lipid phenotypes. These results will facilitate investigation of the roles of iron in disease.
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/11/2014 10:37
Dernière modification de la notice
08/05/2019 21:40
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