Fibroblast Growth Factor-23 (FGF-23) Levels Differ Across Populations by Degree of Industrialization.

Détails

ID Serval
serval:BIB_8A9FC208D15C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Fibroblast Growth Factor-23 (FGF-23) Levels Differ Across Populations by Degree of Industrialization.
Périodique
Journal of Clinical Endocrinology and Metabolism
Auteur(s)
Yuen S.N., Kramer H., Luke A., Bovet P., Plange-Rhule J., Forrester T., Lambert V., Wolf M., Camacho P., Harders R., Dugas L., Cooper R., Durazo-Arvizu R.
ISSN
1945-7197 (Electronic)
ISSN-L
0021-972X
Statut éditorial
Publié
Date de publication
2016
Volume
101
Numéro
5
Pages
2246-2253
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
CONTEXT: Compensatory increases in fibroblast growth factor 23 (FGF23) with increasing phosphate intake may adversely impact health. However, population and clinical studies examining the link between phosphate intake and FGF23 levels have focused mainly on populations living in highly industrialized societies in which phosphate exposure may be homogenous.
OBJECTIVE: The objective of the study was to contrast dietary phosphate intake, urinary measures of phosphate excretion, and FGF23 levels across populations that differ by the level of industrialization.
DESIGN: This was a cross-sectional analysis of three populations.
SETTING: The study was conducted in Maywood, Illinois; Mahé Island, Seychelles; and Kumasi, Ghana.
PARTICIPANTS: Adults with African ancestry aged 25-45 years participated in the study.
MAIN OUTCOME: FGF23 levels were measured.
RESULTS: The mean age was 35.1 (6.3) years and 47.9% were male. Mean phosphate intake and fractional excretion of phosphate were significantly higher in the United States vs Ghana, whereas no significant difference in phosphate intake or fractional excretion of phosphate was noted between the United States and Seychelles for men or women. Overall, median FGF23 values were 57.41 RU/mL (interquartile range [IQR] 43.42, 75.09) in the United States, 42.49 RU/mL (IQR 33.06, 55.39) in Seychelles, and 33.32 RU/mL (IQR 24.83, 47.36) in Ghana. In the pooled sample, FGF23 levels were significantly and positively correlated with dietary phosphate intake (r = 0.11; P < .001) and the fractional excretion of phosphate (r = 0.13; P < .001) but not with plasma phosphate levels (r = -0.001; P = .8). Dietary phosphate intake was significantly and positively associated with the fractional excretion of phosphate (r = 0.23; P < .001).
CONCLUSION: The distribution of FGF23 levels in a given population may be influenced by the level of industrialization, likely due to differences in access to foods preserved with phosphate additives.
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/03/2016 12:56
Dernière modification de la notice
08/05/2019 21:40
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