L-dopa-induced dyskinesia improvement after STN-DBS depends upon medication reduction
Details
Serval ID
serval:BIB_8A7FC753084F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
L-dopa-induced dyskinesia improvement after STN-DBS depends upon medication reduction
Journal
Neurology
ISSN
1526-632X (Electronic)
Publication state
Published
Issued date
07/2004
Volume
63
Number
1
Pages
153-5
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 13
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 13
Abstract
The authors studied the long-term evolution of levodopa-induced dyskinesia (LID) after levodopa challenge in two groups of six STN-deep brain stimulation-treated Parkinson disease (PD) patients, one requiring medication after surgery and the other not. A dramatic (96%) reduction of LID severity was obtained in the six postoperatively untreated patients compared to a moderate improvement (47%) in the treated group (p < 0.03). These data support dopaminergic stimulation and striatal desensitization as major determinants of LID in PD.
Keywords
Aged
Aged, 80 and over
Antiparkinson Agents/administration & dosage/*adverse effects/diagnostic
use/therapeutic use
Combined Modality Therapy
Corpus Striatum/physiopathology
*Deep Brain Stimulation
Dose-Response Relationship, Drug
Dyskinesia, Drug-Induced/*etiology/physiopathology
Female
Humans
Levodopa/administration & dosage/*adverse effects/diagnostic
use/therapeutic use
Male
Middle Aged
Parkinson Disease/drug therapy/*therapy
Receptors, Dopamine/drug effects
Severity of Illness Index
Pubmed
Web of science
Create date
25/01/2008 12:48
Last modification date
20/08/2019 14:49
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