Differential nitric oxide synthase activity in human platelets during normal pregnancy and pre-eclampsia.

Détails

ID Serval
serval:BIB_8A71038D4654
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Differential nitric oxide synthase activity in human platelets during normal pregnancy and pre-eclampsia.
Périodique
Clinical Science
Auteur(s)
Delacrétaz E., de Quay N., Waeber B., Vial Y., Schulz P.E., Burnier M., Brunner H.R., Bossart H., Schaad N.C.
ISSN
0143-5221
Statut éditorial
Publié
Date de publication
06/1995
Peer-reviewed
Oui
Volume
88
Numéro
6
Pages
607-610
Langue
anglais
Notes
Publication types: Comparative Study
Résumé
1. Nitric oxide released from endothelial cells is a potent vasodilator that might play an important role in cardiovascular regulation during pregnancy. Platelets, like endothelial cells, contain a constitutive form of nitric oxide synthase. 2. The present study aimed to measure the activity of this nitric oxide-forming enzyme in normotensive pregnant and non-pregnant women, as well as in women who had developed pre-eclampsia. Nitric oxide synthase activity was measured in the platelets of 21 normotensive pregnant women, 16 non-pregnant women and seven pregnant women who had developed pre-eclampsia. 3. The nitric oxide synthase activity was significantly higher in normotensive pregnant women [36.8 +/- 2.7 pmol h-1 mg-1 of protein (mean +/- SEM), P < 0.001] than in non-pregnant control subjects (16.8 +/- 1.4 pmol h-1 mg-1 of protein) and in women with pre-eclampsia (24.5 +/- 2.1 pmol h-1 mg-1 of protein, P < 0.01). 4. These data suggest that nitric oxide synthesis is increased during normal pregnancy, possibly contributing to the vasodilatation associated with this condition. Nitric oxide generation, however, may be inappropriately low in pregnant women developing pre-eclampsia, thus leading to an enhanced vasoconstriction.
Mots-clé
Adult, Amino Acid Oxidoreductases/metabolism, Blood Platelets/enzymology, Calmodulin-Binding Proteins/metabolism, Female, Humans, Nitric Oxide Synthase, Pre-Eclampsia/blood, Pre-Eclampsia/enzymology, Pregnancy/blood, Pregnancy/metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 13:56
Dernière modification de la notice
03/03/2018 19:09
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