Critical role of endogenous Mtv in acute lethal graft-versus-host disease

Détails

ID Serval
serval:BIB_8A695FC9BE3F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Critical role of endogenous Mtv in acute lethal graft-versus-host disease
Périodique
European Journal of Immunology
Auteur(s)
Miconnet  I., Roger  T., Seman  M., Bruley-Rosset  M.
ISSN
0014-2980 (Print)
Statut éditorial
Publié
Date de publication
02/1995
Volume
25
Numéro
2
Pages
364-8
Notes
Journal Article --- Old month value: Feb
Résumé
Little is known about the etiology of the graft-versus-host disease (GVHD) occuring after transplantation of lymphoid cells incompatible for minor histocompatibility antigens (mHAg). Here, the potential role of host endogenous mouse mammary tumor virus (Mtv)-encoded superantigens (SAg) in the development of lethal GVHD was investigated. In a combination of H-2d compatible mice, the presence of Mtv-7 and, to a lesser extent, of Mtv-1, -6, -13 in the host genome, highly increases the rate and severity of GVHD. Kinetic analyses of TCR V beta gene expression in recipient mice consistently indicate a dramatic but transient infiltration of GVHD target organs by Mtv-SAg-specific T cells. This suggests that SAg encoded by endogenous Mtv, by activating large T cell subpopulations, would help the response to mHAg and thus play a critical role in the initiation or aggravation of GVHD.
Mots-clé
Acute Disease Animals Graft vs Host Disease/*etiology/mortality Mammary Tumor Virus, Mouse/immunology/*physiology Mice Mice, Inbred Strains Proviruses/*physiology Receptors, Antigen, T-Cell, alpha-beta/analysis Superantigens/*physiology T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 16:08
Dernière modification de la notice
03/03/2018 19:09
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