Advances in vaccination against Helicobacter pylori.

Détails

ID Serval
serval:BIB_8A4025718FA2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Advances in vaccination against Helicobacter pylori.
Périodique
Expert Review of Gastroenterology and Hepatology
Auteur(s)
Velin D., Michetti P.
ISSN
1747-4132 (Electronic)
ISSN-L
1747-4124
Statut éditorial
Publié
Date de publication
2010
Volume
4
Numéro
2
Pages
157-166
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
A vaccination against Helicobacter pylori may represent both prophylactic and therapeutic approaches to the control of H. pylori infection. Different protective H. pylori-derived antigens, such as urease, vacuolating cytotoxin A, cytotoxin-associated antigen, neutrophil-activating protein and others can be produced at low cost in prokaryote expression systems and most of these antigens have already been administered to humans and shown to be safe. The recent development by Graham et al. of the model of H. pylori challenge in humans, the recent published clinical trials and the last insight generated in animal models of H. pylori infection regarding the immune mechanisms leading to vaccine-induced Helicobacter clearance will facilitate the evaluation of immunogenicity and efficacy of H. pylori vaccine candidates in Phase II and III clinical trials.
Mots-clé
Animals, Antigens, Bacterial/immunology, Bacterial Vaccines/therapeutic use, Cats, Disease Models, Animal, Dogs, Guinea Pigs, Helicobacter Infections/immunology, Helicobacter Infections/prevention & control, Helicobacter pylori/immunology, Humans, Immunity, Mucosal/immunology, Mice, Swine
Pubmed
Web of science
Création de la notice
01/10/2010 18:53
Dernière modification de la notice
03/03/2018 19:09
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